{"id":"W4400822074","doi":"10.21203/rs.3.rs-4502680/v1","title":"The effect of family structure on the still-missing heritability and genomic prediction accuracy of type 2 diabetes","year":2024,"lang":"en","type":"preprint","venue":"Research Square","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Dalhousie University","funders":"","keywords":"Missing heritability problem; Heritability; Type 2 diabetes; Type (biology); Medicine; Diabetes mellitus; Computational biology; Genetics; Biology; Internal medicine; Endocrinology; Gene; Genetic variants; Genotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.04486002,0.001347136,0.002278113,0.001740278,0.001219035,0.002956378,0.002203106,0.004125005,0.007477958],"category_scores_gemma":[0.1849236,0.001230142,0.002810008,0.002017814,0.003679524,0.003395218,0.002247751,0.004918812,0.0009878648],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000495757,"about_ca_system_score_gemma":0.000819449,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004387874,"about_ca_topic_score_gemma":0.00278902,"domain_scores_codex":[0.9561529,0.0308347,0.001509996,0.008014469,0.001707186,0.001780607],"domain_scores_gemma":[0.4037641,0.5414771,0.008435632,0.03896882,0.004213205,0.003141052],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00299292,0.0002122843,0.9277837,0.0001902204,0.00590599,0.001220715,0.000657096,0.01201557,0.002030645,0.004395276,0.003120883,0.03947467],"study_design_scores_gemma":[0.000403797,0.0005819847,0.877259,0.0002237541,0.006230027,0.00225276,0.0004806961,0.06866281,0.002280834,0.04002525,0.001436444,0.0001625014],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9429842,0.006984897,0.03049088,0.01102867,0.0006170119,0.00002614325,0.003738671,0.0005867931,0.003542674],"genre_scores_gemma":[0.995758,0.0003337307,0.001943567,0.00031293,0.0003826807,0.00001163111,0.0005870051,0.00009503544,0.0005754448],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04486002,"threshold_uncertainty_score":0.2372453,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02785001169405435,"score_gpt":0.3601721612058291,"score_spread":0.3323221495117747,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}