{"id":"W4400823177","doi":"10.3390/cells13141216","title":"Graft-Specific Regulatory T Cells for Long-Lasting, Local Tolerance Induction","year":2024,"lang":"en","type":"article","venue":"Cells","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto General Hospital; University of Toronto; University Health Network","funders":"Medizinischen Hochschule Hannover; Deutsche Forschungsgemeinschaft; Government of Canada","keywords":"Immune system; Immune tolerance; Immunology; Transplantation; Regulatory T cell; Organ transplantation; Graft rejection; Medicine; Immunity; Biology; T cell; Cancer research; IL-2 receptor; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002305601,0.0002823267,0.0003247176,0.0001586993,0.0002367895,0.00004588485,0.0002686981,0.0005260505,0.0008912372],"category_scores_gemma":[0.000005838377,0.00025762,0.000198458,0.0001946745,0.0004729036,0.0001260419,0.00007388332,0.0004877726,0.003876855],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008397364,"about_ca_system_score_gemma":0.00007339159,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001549011,"about_ca_topic_score_gemma":0.000007734263,"domain_scores_codex":[0.9982783,0.0001018083,0.0003822737,0.0006243578,0.00003982719,0.000573424],"domain_scores_gemma":[0.9992241,0.0001907998,0.00008183261,0.00039993,0.00007222266,0.00003110265],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009231832,0.00009261422,0.00001393734,0.00009426131,0.00009315186,0.00001469966,0.0002158833,0.00006736313,0.9002514,0.0008708781,0.07503733,0.02315616],"study_design_scores_gemma":[0.0004385329,0.0001244096,0.0000521691,0.00005303313,0.00002697292,0.00004203835,0.00007288812,0.00003122283,0.5843996,0.0001801446,0.4143928,0.0001861974],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8909653,0.05246108,0.02490097,0.0003835885,0.02724508,0.0008774898,0.00007972681,0.000693462,0.002393348],"genre_scores_gemma":[0.9595793,0.00034162,0.0001559407,0.000120932,0.0003164881,0.00005740071,0.0001043184,0.00005234247,0.03927159],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3393555,"threshold_uncertainty_score":0.9999876,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01458279599839952,"score_gpt":0.2215650503497294,"score_spread":0.2069822543513299,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}