{"id":"W4400835559","doi":"10.54254/2753-8818/16/20240550","title":"Review of mutant p53 protein and the p53 targeting therapy in cancer treatment","year":2023,"lang":"en","type":"article","venue":"Theoretical and Natural Science","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Bishop's University","funders":"","keywords":"Mutant; P53 protein; Cancer; Cancer research; Cancer therapy; Medicine; Biology; Internal medicine; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004239119,0.0005731535,0.0009111601,0.002143819,0.0002814096,0.0007339998,0.0006474788,0.0008850929,0.00372962],"category_scores_gemma":[0.0006128711,0.0002093534,0.0005478439,0.002252135,0.0003705867,0.001052413,0.000409629,0.001392216,0.001449632],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005652902,"about_ca_system_score_gemma":0.0008151504,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007210366,"about_ca_topic_score_gemma":0.001337917,"domain_scores_codex":[0.9998086,0.00004596779,0.00002861116,0.00003062562,0.00007076504,0.00001539244],"domain_scores_gemma":[0.9997458,0.0001305883,0.00003326832,0.000007952699,0.00006086428,0.00002146983],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"systematic_review","study_design_scores_codex":[0.0001553934,0.0001693851,0.0002076071,0.02958314,0.0001226725,0.0004711957,0.0001444161,0.0007233798,0.004236354,0.008813582,0.1089658,0.8464071],"study_design_scores_gemma":[0.000009167042,0.0001190022,0.0004485749,0.002453227,0.0000703768,0.00118382,0.00003429705,0.00007387639,0.0004994944,0.001426406,0.9936702,0.00001149406],"study_design_candidate":"systematic_review","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001710044,0.9970338,0.0001751466,0.000414106,0.0005470423,0.000005786681,0.00001842922,0.000005733194,0.001628966],"genre_scores_gemma":[0.0007828025,0.997218,0.0002244245,0.0003460172,0.0004735824,0.000008763954,0.00003114728,0.000002198909,0.0009130617],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.00372962,"threshold_uncertainty_score":0.0124768,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01057745220985237,"score_gpt":0.2999481797052483,"score_spread":0.289370727495396,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}