{"id":"W4400850181","doi":"10.1016/j.redox.2024.103276","title":"Metastatic breast cancer cells are metabolically reprogrammed to maintain redox homeostasis during metastasis","year":2024,"lang":"en","type":"article","venue":"Redox Biology","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; Jewish General Hospital; Montreal Neurological Institute and Hospital; University of Ottawa; McGill University","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Terry Fox Foundation; Fondation du cancer du sein du Québec; McGill University","keywords":"GCLC; GCLM; Metastatic breast cancer; Metastasis; Cancer research; Breast cancer; Glutathione; Biology; Cancer cell; Cancer; Internal medicine; Medicine; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000527815,0.000477871,0.0007083931,0.0002780746,0.0001421622,0.0001036853,0.0004443571,0.0002679265,0.0002722032],"category_scores_gemma":[0.0001079589,0.000414774,0.0004238466,0.0006321305,0.0001875656,0.00001136465,0.0003380056,0.0002635312,0.00009927378],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007414934,"about_ca_system_score_gemma":0.0002423101,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004078185,"about_ca_topic_score_gemma":0.0004147421,"domain_scores_codex":[0.996658,0.0002835821,0.0005571524,0.001355443,0.000190489,0.0009553902],"domain_scores_gemma":[0.9983829,0.0000382701,0.0001361257,0.0008574801,0.0001734768,0.0004117569],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003099387,0.00009520392,0.0001602128,0.000144322,0.0009098477,0.0000295271,0.00008356973,0.00006703028,0.8870052,0.0006241548,0.008757627,0.1018134],"study_design_scores_gemma":[0.0006511391,0.0001530294,0.002846925,0.00006233203,0.0004226207,0.0002255675,0.0001792,0.00001808297,0.2598103,0.0002517674,0.7347791,0.0005998526],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9012848,0.0808913,0.00254754,0.005322003,0.005068124,0.00110792,0.003289803,0.0002391375,0.0002493542],"genre_scores_gemma":[0.9739754,0.01315758,0.004858157,0.00138595,0.003752731,0.0006629155,0.0003149266,0.0001524536,0.001739955],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7260215,"threshold_uncertainty_score":0.9998304,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01018733010674153,"score_gpt":0.2813524585871423,"score_spread":0.2711651284804008,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}