{"id":"W4400866623","doi":"10.1016/j.exppara.2024.108800","title":"Mevalonate kinase of Leishmania donovani promotes its survival and plays a pivotal role in pathogenesis","year":2024,"lang":"en","type":"article","venue":"Experimental Parasitology","topic":"Research on Leishmaniasis Studies","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"University Grants Commission; Indian Council of Medical Research; McGill University","keywords":"Biology; Leishmania donovani; Macrophage; Leishmania; Microbiology; Macrophage polarization; Cytokine; Molecular biology; Immunology; Visceral leishmaniasis; Leishmaniasis; Biochemistry; In vitro; Parasite hosting","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001791053,0.0005578203,0.0002646509,0.0003688107,0.0003232993,0.0005987301,0.0001681878,0.0004100351,0.00178367],"category_scores_gemma":[0.0001419312,0.0001586315,0.0002277586,0.0001222111,0.0003608472,0.000496643,0.0003878908,0.000452828,0.0003947225],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003254433,"about_ca_system_score_gemma":0.0003367203,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002601976,"about_ca_topic_score_gemma":0.0002962705,"domain_scores_codex":[0.9998354,0.0000451134,0.00001157009,0.00003179553,0.00002820175,0.00004793923],"domain_scores_gemma":[0.9999089,0.00001115409,0.00002556408,0.000008202649,0.00002014038,0.00002603797],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006597151,0.00004685009,0.0009854609,0.000262056,0.00001348151,0.000208706,0.00005000707,0.00008061089,0.9921611,0.001447038,0.0001665525,0.003918381],"study_design_scores_gemma":[0.00007764809,0.0006273797,0.01853533,0.00004999348,0.00005002396,0.002119755,0.0004355721,0.0006886318,0.9551645,0.001377517,0.02085437,0.0000192925],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9604529,0.02886474,0.003183678,0.000910186,0.0002793807,0.00004756336,0.0004482691,0.0001027313,0.005710618],"genre_scores_gemma":[0.9939674,0.002703456,0.0008044254,0.00004557897,0.00002967787,0.00001450431,0.0002867816,0.000007168073,0.00214109],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00178367,"threshold_uncertainty_score":0.005966961,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02835945353320902,"score_gpt":0.3562396118915448,"score_spread":0.3278801583583358,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}