{"id":"W4400871417","doi":"10.1016/j.ejmech.2024.116692","title":"Candida antarctica Lipase B mediated kinetic resolution: A sustainable method for chiral synthesis of antiproliferative β-lactams","year":2024,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Enzyme Catalysis and Immobilization","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Trinity College","funders":"Trinity College Dublin; Royal Society of Chemistry","keywords":"Chemistry; Kinetic resolution; Enantiomer; Substituent; Biocatalysis; Candida antarctica; Lactam; Stereochemistry; Enantiomeric excess; Enantioselective synthesis; Diastereomer; Substrate (aquarium); Racemic mixture; Lipase; Combinatorial chemistry; Organic chemistry; Catalysis; Enzyme; Reaction mechanism","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001483069,0.0001564731,0.0002822741,0.00006100536,0.00005347798,0.00002522698,0.000206206,0.00005811674,0.0000513542],"category_scores_gemma":[0.001518821,0.000123406,0.0001923263,0.0001757524,0.0001073926,0.00001163078,0.00005056091,0.000171809,0.000001127974],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003412384,"about_ca_system_score_gemma":0.0002353424,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003940176,"about_ca_topic_score_gemma":4.139297e-7,"domain_scores_codex":[0.9986059,0.000172649,0.0005513098,0.0002202659,0.0002357276,0.0002141512],"domain_scores_gemma":[0.9988521,0.0001229005,0.0002676537,0.0001842696,0.000437778,0.0001352561],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005046497,0.00006919117,0.00005559804,0.0007026949,0.0002574068,0.0001621806,0.0001870664,0.00009912205,0.9892899,0.00003454002,0.007227616,0.001409985],"study_design_scores_gemma":[0.0007214939,0.0006719411,0.0001077356,0.0003891255,0.0002827276,0.0003954477,0.0007617001,0.0009079215,0.955648,0.00002152851,0.03994323,0.0001491097],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8103855,0.02113835,0.1538475,0.001889272,0.0005113375,0.0004774943,0.0001339159,0.00003036342,0.0115863],"genre_scores_gemma":[0.9950119,0.0003535035,0.002448417,0.00007290778,0.00092843,0.000004627037,0.00008224518,0.00003486825,0.001063141],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1846264,"threshold_uncertainty_score":0.503235,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007885369477850939,"score_gpt":0.264925440759813,"score_spread":0.257040071281962,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}