{"id":"W4400884974","doi":"10.1177/10915818241263068","title":"Preclinical Safety Evaluation of Etripamil Nasal Spray in Cynomolgus Macaques ( <i>Macaca fascicularis</i> ) to Assess for Safety in Patients With Paroxysmal Supraventricular Tachycardia","year":2024,"lang":"en","type":"article","venue":"International Journal of Toxicology","topic":"Cardiac Arrhythmias and Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vertex Pharmaceuticals (Canada)","funders":"","keywords":"Medicine; Nasal administration; Nostril; Nasal cavity; No-observed-adverse-effect level; Toxicity; Adverse effect; Systemic administration; Anesthesia; Mucous membrane of nose; Nose; Pharmacology; Internal medicine; Pathology; Surgery; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001814991,0.0001611717,0.0005824055,0.0006255856,0.00001507605,0.00002168291,0.0001452975,0.0001712148,0.00007814931],"category_scores_gemma":[0.0007323695,0.0001232496,0.0002988896,0.0002558432,0.00004329445,0.0001562368,0.00005815594,0.0003218787,0.000003542211],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000927548,"about_ca_system_score_gemma":0.0005898143,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002570984,"about_ca_topic_score_gemma":0.00006938384,"domain_scores_codex":[0.997211,0.0002556022,0.001017287,0.0002591846,0.001041822,0.0002150849],"domain_scores_gemma":[0.9979132,0.0004931331,0.0002605762,0.0001202834,0.001094756,0.0001180134],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01317142,0.001448343,0.9278709,0.00007171779,0.001882389,0.001277767,0.0002872069,0.00521127,0.0002779286,0.0003569784,0.0004819519,0.04766206],"study_design_scores_gemma":[0.01468528,0.002253062,0.9741024,0.0005062207,0.0005024001,0.0003279999,0.00004839518,0.0008303973,0.001285038,0.0002134379,0.005106903,0.0001384988],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933244,0.0004905952,0.001391288,0.001596772,0.001627695,0.0009609532,0.0001534769,0.000006646136,0.0004481717],"genre_scores_gemma":[0.997595,0.00005979915,0.001570482,0.0002130665,0.0003718789,0.00003583327,0.0001049536,0.0000201918,0.00002886763],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04752357,"threshold_uncertainty_score":0.5025972,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03502858107501596,"score_gpt":0.3819688553951731,"score_spread":0.3469402743201572,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}