{"id":"W4400884974","doi":"10.1177/10915818241263068","title":"Preclinical Safety Evaluation of Etripamil Nasal Spray in Cynomolgus Macaques ( <i>Macaca fascicularis</i> ) to Assess for Safety in Patients With Paroxysmal Supraventricular Tachycardia","year":2024,"lang":"en","type":"article","venue":"International Journal of Toxicology","topic":"Cardiac Arrhythmias and Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vertex Pharmaceuticals (Canada)","funders":"","keywords":"Medicine; Nasal administration; Nostril; Nasal cavity; No-observed-adverse-effect level; Toxicity; Adverse effect; Systemic administration; Anesthesia; Mucous membrane of nose; Nose; Pharmacology; Internal medicine; Pathology; Surgery; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005595133,0.0004366444,0.0004590634,0.0002799757,0.0003072728,0.00039301,0.0003429611,0.000467679,0.001685026],"category_scores_gemma":[0.0003240689,0.0001815572,0.0003734557,0.0001299325,0.0003074944,0.0003193905,0.0001407903,0.0009279635,0.0004206023],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003803556,"about_ca_system_score_gemma":0.0004442016,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002186727,"about_ca_topic_score_gemma":0.004527357,"domain_scores_codex":[0.9998074,0.0000527835,0.00001343769,0.00003436732,0.00004114635,0.00005082616],"domain_scores_gemma":[0.9997235,0.00003174032,0.00006604114,0.00003179028,0.00008295423,0.00006399583],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004195886,0.003245296,0.001373042,0.0002415126,0.00008723971,0.0002328526,0.00020793,0.0004929742,0.9714575,0.0001479683,0.0009361058,0.01738167],"study_design_scores_gemma":[0.002468344,0.3535537,0.042858,0.0001763707,0.0005755218,0.00219705,0.000566024,0.004844727,0.5666384,0.000296878,0.02576293,0.00006204128],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933069,0.001832349,0.001456416,0.0002578905,0.00007185167,0.0005848782,0.0005823627,0.00008338326,0.001823868],"genre_scores_gemma":[0.9920011,0.001726194,0.002043039,0.000222605,0.00004033507,0.0006317497,0.0008228397,0.00002016968,0.002491983],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002186727,"threshold_uncertainty_score":0.00563699,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03502858107501596,"score_gpt":0.3819688553951731,"score_spread":0.3469402743201572,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}