{"id":"W4400886163","doi":"10.3390/v16071167","title":"NTB-A and 2B4 Natural Killer Cell Receptors Modulate the Capacity of a Cocktail of Non-Neutralizing Antibodies and a Small CD4-Mimetic to Eliminate HIV-1-Infected Cells by Antibody-Dependent Cellular Cytotoxicity","year":2024,"lang":"en","type":"article","venue":"Viruses","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier de l’Université de Montréal","funders":"Fonds de Recherche du Québec - Santé; National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; National Institutes of Health; Mitacs","keywords":"Antibody-dependent cell-mediated cytotoxicity; Epitope; Receptor; CD16; Antibody; Fc receptor; Cell biology; Chemistry; Tetherin; Biology; Virology; Immune system; Immunology; Viral envelope; Monoclonal antibody; Biochemistry; CD3; CD8","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008334712,0.0002186736,0.0001801099,0.00008503941,0.0000659244,0.0002006581,0.000214455,0.0002312095,0.001984215],"category_scores_gemma":[0.0001274008,0.00009908269,0.0001536141,0.00006704012,0.00011516,0.0001979,0.000132123,0.0002972967,0.0003087046],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002111617,"about_ca_system_score_gemma":0.0001485424,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000398196,"about_ca_topic_score_gemma":0.0003092622,"domain_scores_codex":[0.9998825,0.0000223235,0.000006934571,0.00001145013,0.00002684961,0.00005003057],"domain_scores_gemma":[0.9999715,0.000005969652,0.000006688639,0.00000233528,0.000004196395,0.000009373756],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001896305,0.00007020337,0.0001599974,0.00003893302,0.000004028303,0.00004362857,0.000005891812,0.0001888624,0.996768,0.0001444331,0.00006002299,0.00232638],"study_design_scores_gemma":[0.00008540905,0.001414436,0.004275074,0.00001000132,0.00002651972,0.0003143988,0.00002476771,0.00321749,0.9853144,0.0001398587,0.005170221,0.000007419904],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933924,0.003034348,0.0009660788,0.00006333207,0.0000251815,0.00004178393,0.0001024891,0.00003064014,0.00234364],"genre_scores_gemma":[0.9952002,0.001281841,0.0007687083,0.00004320196,0.00001085546,0.00004877743,0.0001289363,0.000005023964,0.002512556],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001984215,"threshold_uncertainty_score":0.006637812,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01303546952867503,"score_gpt":0.2378240630711454,"score_spread":0.2247885935424704,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}