{"id":"W4400892363","doi":"10.1136/jitc-2024-009427","title":"Biomarker development for PD-(L)1 axis inhibition: a consensus view from the SITC Biomarkers Committee","year":2024,"lang":"en","type":"review","venue":"Journal for ImmunoTherapy of Cancer","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital","funders":"Kite Pharma; Moderna; EMD Serono; Ribon Therapeutics; Regeneron Pharmaceuticals; Gilead Sciences; Genentech; Society for Immunotherapy of Cancer; AstraZeneca; Eli Lilly and Company; Bristol-Myers Squibb","keywords":"Biomarker; Medicine; Immunotherapy; PD-L1; Biomarker discovery; Immune system; Oncology; Bioinformatics; Immunology; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001611068,0.0009192,0.002806382,0.0003753217,0.0005062867,0.0001835156,0.0004805077,0.0005542822,0.0006912531],"category_scores_gemma":[0.00005101976,0.0005327238,0.003250766,0.0006332095,0.0003960717,0.00006953733,0.00005323425,0.0006879066,0.000013756],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001060042,"about_ca_system_score_gemma":0.003305807,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000174554,"about_ca_topic_score_gemma":0.0001013627,"domain_scores_codex":[0.9954621,0.0001888421,0.002498804,0.000593996,0.0006253444,0.0006309195],"domain_scores_gemma":[0.9959581,0.00112351,0.001585062,0.0006629691,0.0005205758,0.0001498059],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.004012865,0.0001126621,0.000005150357,0.007843366,0.01620394,0.00001609522,0.0003221358,9.017722e-8,0.0003372576,0.00001670752,0.1337627,0.8373671],"study_design_scores_gemma":[0.00494217,0.0004075428,0.00004351959,0.04903783,0.004292123,0.0003676866,0.0001195148,0.000004463681,0.000210513,0.0001764231,0.939813,0.0005851983],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00014602,0.9863213,0.0003199156,0.003517127,0.003578066,0.004532285,0.001445337,0.00005272135,0.00008726333],"genre_scores_gemma":[0.00001470529,0.9908858,0.002928798,0.001265524,0.001101071,0.001503235,0.0002872783,0.0002677524,0.001745847],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.8367819,"threshold_uncertainty_score":0.9997124,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08405559566590562,"score_gpt":0.3973262209989202,"score_spread":0.3132706253330145,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}