{"id":"W4400892363","doi":"10.1136/jitc-2024-009427","title":"Biomarker development for PD-(L)1 axis inhibition: a consensus view from the SITC Biomarkers Committee","year":2024,"lang":"en","type":"review","venue":"Journal for ImmunoTherapy of Cancer","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital","funders":"Kite Pharma; Moderna; EMD Serono; Ribon Therapeutics; Regeneron Pharmaceuticals; Gilead Sciences; Genentech; Society for Immunotherapy of Cancer; AstraZeneca; Eli Lilly and Company; Bristol-Myers Squibb","keywords":"Biomarker; Medicine; Immunotherapy; PD-L1; Biomarker discovery; Immune system; Oncology; Bioinformatics; Immunology; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01601249,0.0009756474,0.002643322,0.003017334,0.0005603491,0.003347955,0.002902602,0.005384851,0.002885394],"category_scores_gemma":[0.00982923,0.0005254403,0.001673096,0.002402894,0.001146356,0.004806373,0.002370052,0.009152049,0.003451148],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002232807,"about_ca_system_score_gemma":0.01123438,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001427711,"about_ca_topic_score_gemma":0.002126203,"domain_scores_codex":[0.9968184,0.0008722304,0.0005507334,0.0002843123,0.001225923,0.0002482123],"domain_scores_gemma":[0.990807,0.002638013,0.0007833567,0.0002197134,0.004733027,0.0008189356],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001406279,0.00008980002,0.000311032,0.006479651,0.00009292028,0.0001587189,0.0000747018,0.000331369,0.001436713,0.01320042,0.2462714,0.7314128],"study_design_scores_gemma":[0.00004044596,0.0001020936,0.0002682745,0.005508993,0.00007256076,0.0003583425,0.0000383102,0.0001267673,0.0004335938,0.003585928,0.9894434,0.00002136611],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002261423,0.9320406,0.002183403,0.05400766,0.007574278,0.0001292486,0.0001466838,0.00006717129,0.003624764],"genre_scores_gemma":[0.001808851,0.959272,0.005689661,0.02497056,0.003722047,0.0002186421,0.0004146616,0.00003269172,0.003870864],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.01601249,"threshold_uncertainty_score":0.08468318,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08405559566590562,"score_gpt":0.3973262209989202,"score_spread":0.3132706253330145,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}