{"id":"W4400892533","doi":"10.1136/jitc-2024-009309","title":"Osteoporotic fractures: an unrecognized adverse event of immune checkpoint inhibitors?","year":2024,"lang":"en","type":"review","venue":"Journal for ImmunoTherapy of Cancer","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research; Cancer Research Society","keywords":"Adverse effect; Medicine; Osteoporosis; Immune system; Bone remodeling; Intensive care medicine; Bioinformatics; Internal medicine; Oncology; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001694603,0.0008096019,0.004053831,0.0007645342,0.0001204222,0.00004097169,0.0004688576,0.0006135521,0.001391315],"category_scores_gemma":[0.00006659178,0.0005414472,0.00568368,0.0005711321,0.0002355067,0.000192796,0.00003732053,0.001064558,0.000006939257],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007706435,"about_ca_system_score_gemma":0.002645447,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002371251,"about_ca_topic_score_gemma":0.00002804205,"domain_scores_codex":[0.9942569,0.0001673755,0.003870511,0.0004753818,0.0007321436,0.0004977154],"domain_scores_gemma":[0.9950271,0.000159745,0.003384053,0.0007252317,0.0005247322,0.0001791256],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.004992928,0.0003471319,0.000003016229,0.02691463,0.006774016,0.00001717526,0.0005630652,0.000002353264,0.003864744,0.000004271613,0.001224881,0.9552918],"study_design_scores_gemma":[0.005603979,0.002101716,0.00003341037,0.06794796,0.004834194,0.0003850349,0.0001673796,0.000005067869,0.002839755,0.0001108333,0.9154757,0.0004949438],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001198819,0.990936,0.00005639869,0.0001754514,0.0046185,0.002563199,0.0003491544,0.00003186372,0.00007059639],"genre_scores_gemma":[0.0002890129,0.9953764,0.0005113684,0.0001254494,0.001206666,0.0002885888,0.000112534,0.0002692971,0.001820653],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9547969,"threshold_uncertainty_score":0.9997037,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03742799908571104,"score_gpt":0.4110232161316989,"score_spread":0.3735952170459879,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}