{"id":"W4400895607","doi":"10.1101/2024.07.19.24310476","title":"Multiomic Analyses Direct Hypotheses for Creutzfeldt-Jakob Disease Risk Genes","year":2024,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Public Health Agency of Canada; University of Toronto; University Health Network","funders":"Medical Research Council; Charles F. and Joanne Knight Alzheimer Disease Research Center, Washington University in St. Louis; Arizona Biomedical Research Commission; National Institutes of Health; Rush University; National Center for Geriatrics and Gerontology; Universiteit Antwerpen; National Institute for Health and Care Research; National Institute on Aging; University of Washington; Arizona Department of Health Services","keywords":"Disease; Gene; Biology; Computational biology; Computer science; Medicine; Genetics; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002516326,0.000891791,0.0008726802,0.002997706,0.0008762108,0.001958624,0.0006261909,0.0005650689,0.003096167],"category_scores_gemma":[0.004384079,0.0002968065,0.002478143,0.001973853,0.0005748757,0.0006270559,0.001651281,0.001057735,0.0005748725],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005103431,"about_ca_system_score_gemma":0.0008255993,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002573402,"about_ca_topic_score_gemma":0.002701599,"domain_scores_codex":[0.9985159,0.0003314844,0.00008997142,0.0006908941,0.0001901954,0.0001815449],"domain_scores_gemma":[0.9975343,0.001314294,0.0003597205,0.0002281321,0.0002916995,0.0002718666],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001557062,0.0002618256,0.7028053,0.0006268964,0.003173189,0.002081842,0.0009679293,0.009152839,0.2174534,0.005863053,0.003152406,0.05290418],"study_design_scores_gemma":[0.0001181896,0.0004120183,0.8605683,0.0001507406,0.002499977,0.001068583,0.001125599,0.08686703,0.01727064,0.02235684,0.007465612,0.00009648353],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9265854,0.001379002,0.06137268,0.000720174,0.0000943436,0.0001097236,0.006838717,0.0006953998,0.002204462],"genre_scores_gemma":[0.9773471,0.0002057974,0.01750318,0.0002314047,0.0000510149,0.00006128225,0.003867036,0.0001989089,0.0005343145],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003096167,"threshold_uncertainty_score":0.01330781,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04973736380464388,"score_gpt":0.3463409416735894,"score_spread":0.2966035778689455,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}