{"id":"W4400904819","doi":"10.3390/vaccines12080830","title":"Formulation Development of a COVID-19 Recombinant Spike Protein-Based Vaccine","year":2024,"lang":"en","type":"article","venue":"Vaccines","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sanofi (Canada)","funders":"Biomedical Advanced Research and Development Authority; Sanofi; U.S. Department of Health and Human Services","keywords":"Coronavirus disease 2019 (COVID-19); Virology; Recombinant DNA; Spike Protein; Spike (software development); Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); 2019-20 coronavirus outbreak; Biology; Computational biology; Computer science; Medicine; Genetics; Outbreak; Infectious disease (medical specialty); Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005152473,0.0001839401,0.0003179254,0.0004882749,0.00008425993,0.00003127201,0.000125247,0.0001003259,0.00009583562],"category_scores_gemma":[0.0004981686,0.000136847,0.0001097103,0.0007046185,0.000007939669,0.00008589888,0.00005124814,0.0001629648,0.00009772705],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002397049,"about_ca_system_score_gemma":0.001809257,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000107619,"about_ca_topic_score_gemma":0.00009481946,"domain_scores_codex":[0.9984599,0.00003221746,0.0004763555,0.0003475456,0.0003882627,0.0002957154],"domain_scores_gemma":[0.999193,0.0001257527,0.00006430636,0.0003157228,0.0002184547,0.00008279909],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003931876,0.001029897,0.08995235,0.01295187,0.0003874931,0.0004267235,0.002144128,0.0000163935,0.7619321,0.002069336,0.008156443,0.1170014],"study_design_scores_gemma":[0.002883268,0.0004165657,0.0104751,0.0005593853,0.00005487142,0.00002746514,0.00007245775,0.005279172,0.5306781,0.0006439323,0.4486932,0.0002165171],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9891367,0.001038564,0.00441576,0.003326812,0.0002054159,0.001151096,0.000003432399,0.0002265022,0.0004957003],"genre_scores_gemma":[0.9896364,0.000002037676,0.002504824,0.007235303,0.0001264852,0.0001841627,0.00001744974,0.00003932894,0.0002539895],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4405368,"threshold_uncertainty_score":0.5580459,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05200162010211531,"score_gpt":0.3638538927356894,"score_spread":0.3118522726335741,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}