{"id":"W4400904819","doi":"10.3390/vaccines12080830","title":"Formulation Development of a COVID-19 Recombinant Spike Protein-Based Vaccine","year":2024,"lang":"en","type":"article","venue":"Vaccines","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sanofi (Canada)","funders":"Biomedical Advanced Research and Development Authority; Sanofi; U.S. Department of Health and Human Services","keywords":"Coronavirus disease 2019 (COVID-19); Virology; Recombinant DNA; Spike Protein; Spike (software development); Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); 2019-20 coronavirus outbreak; Biology; Computational biology; Computer science; Medicine; Genetics; Outbreak; Infectious disease (medical specialty); Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003777879,0.0004522926,0.0004264468,0.0002856581,0.0001582313,0.000357628,0.0003807574,0.0005034677,0.0008575786],"category_scores_gemma":[0.0002442181,0.0001894186,0.0004509937,0.0001761014,0.0001452653,0.0003345706,0.0002927512,0.0007104177,0.0005165027],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004613782,"about_ca_system_score_gemma":0.0003874189,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004884676,"about_ca_topic_score_gemma":0.0007529326,"domain_scores_codex":[0.9997754,0.00003515765,0.00002292911,0.00003583036,0.00009479104,0.00003598528],"domain_scores_gemma":[0.9999287,0.000008761125,0.00001619743,0.000004251408,0.00002724792,0.00001480656],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003572868,0.00007265512,0.00008474832,0.00007702439,0.000009578351,0.00006819117,0.00001443349,0.0004530894,0.9948107,0.0001275463,0.00008172294,0.004164673],"study_design_scores_gemma":[0.00004422943,0.001565744,0.00078509,0.00001804798,0.00004234795,0.0002956658,0.0000212688,0.003858411,0.9839662,0.00007996284,0.009312104,0.00001089337],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9279662,0.006486652,0.05910299,0.0004212163,0.0003702167,0.00104757,0.0007228168,0.0002475418,0.003634683],"genre_scores_gemma":[0.9051534,0.005273414,0.08071002,0.0002581122,0.00007651425,0.000379912,0.001588959,0.00009718594,0.006462377],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008575786,"threshold_uncertainty_score":0.003347576,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05200162010211531,"score_gpt":0.3638538927356894,"score_spread":0.3118522726335741,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}