{"id":"W4400905582","doi":"10.1002/advs.202402757","title":"Personalized Vascularized Models of Breast Cancer Desmoplasia Reveal Biomechanical Determinants of Drug Delivery to the Tumor","year":2024,"lang":"en","type":"article","venue":"Advanced Science","topic":"Cancer Cells and Metastasis","field":"Medicine","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"National Cancer Institute; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; American-Italian Cancer Foundation; Amgen; Fondazione AIRC per la ricerca sul cancro ETS","keywords":"Stromal cell; Breast cancer; Medicine; Desmoplasia; Cancer research; Tumor microenvironment; Drug delivery; SKBR3; Vascular permeability; Pathology; Cancer; Pharmacology; Internal medicine; Chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001060608,0.0002487686,0.0001017255,0.0001656177,0.0001010186,0.0001994184,0.0001491375,0.0002144464,0.001013406],"category_scores_gemma":[0.00005435878,0.0001303474,0.0001183227,0.0001008914,0.0001727755,0.000174667,0.0001635986,0.0004001054,0.0001834103],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003695479,"about_ca_system_score_gemma":0.0001624167,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008635363,"about_ca_topic_score_gemma":0.001462191,"domain_scores_codex":[0.9999255,0.00001518884,0.000004090991,0.00001445185,0.00002712893,0.00001360874],"domain_scores_gemma":[0.9999493,0.000009249397,0.00001772738,0.00000734178,0.000004361775,0.00001187259],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005002919,0.0000264808,0.0001722814,0.00001792259,0.000003410935,0.00003583194,0.00001892963,0.0007980961,0.9976993,0.0002982081,0.00004475304,0.0008346302],"study_design_scores_gemma":[0.00001262711,0.0002434495,0.002643768,0.000004460487,0.00001203127,0.0001686861,0.00003916939,0.007150131,0.9856301,0.0001456182,0.003944424,0.000005639928],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9854202,0.0005845699,0.01156208,0.00009003087,0.00002591411,0.00003135027,0.0003674537,0.00009037342,0.001827993],"genre_scores_gemma":[0.9922167,0.000496872,0.003809884,0.00002921262,0.000003759665,0.00004206537,0.0002813829,0.00001529204,0.003104742],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001013406,"threshold_uncertainty_score":0.003390133,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01943316247122703,"score_gpt":0.3099242612012382,"score_spread":0.2904910987300112,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}