{"id":"W4400909249","doi":"10.1073/pnas.2407546121","title":"Early metformin treatment: An effective approach for targeting fragile X syndrome pathophysiology","year":2024,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Research Foundation of Korea; Canadian Institutes of Health Research; National Research Foundation; FRAXA Research Foundation","keywords":"Fragile X syndrome; Metformin; FMR1; Gene silencing; Pathophysiology; Autism spectrum disorder; Kinase; Medicine; DYRK1A; Protein kinase A; Neuroscience; Biology; Bioinformatics; Autism; Endocrinology; Gene; Genetics; Fragile x; Psychiatry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001052399,0.0003203865,0.0003142264,0.0002500861,0.0001557515,0.0002085193,0.0002500699,0.0004104224,0.001078981],"category_scores_gemma":[0.0001008402,0.00007812109,0.0002187429,0.000069289,0.0001499579,0.0002203898,0.0001979695,0.0008206441,0.0001334923],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000168183,"about_ca_system_score_gemma":0.0002594673,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002725036,"about_ca_topic_score_gemma":0.001083841,"domain_scores_codex":[0.9999503,0.000009004581,0.000004484137,0.000009912732,0.00001360555,0.00001267007],"domain_scores_gemma":[0.9999537,0.000005121776,0.00001402615,0.000003397458,0.000003877921,0.00001972993],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002555696,0.001467711,0.002376855,0.000382939,0.00006551625,0.0006497272,0.00005231707,0.0003195053,0.8909354,0.001025092,0.0007949495,0.09937438],"study_design_scores_gemma":[0.001286128,0.02258155,0.04811189,0.0002295876,0.0003853882,0.002526349,0.0001851754,0.002580304,0.8741858,0.001190041,0.04665895,0.00007885988],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9751912,0.01111187,0.008627248,0.001047967,0.0003244554,0.0001766426,0.0003299447,0.0002657359,0.002925008],"genre_scores_gemma":[0.9770588,0.007740046,0.01084009,0.0004273045,0.00009262645,0.0001467729,0.0002828168,0.0000300569,0.0033814],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001078981,"threshold_uncertainty_score":0.003609598,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01925147351140232,"score_gpt":0.2825603382226932,"score_spread":0.2633088647112909,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}