{"id":"W4400909857","doi":"10.1073/pnas.2406615121","title":"SARS-CoV-2 spike does not interact with the T cell receptor or directly activate T cells","year":2024,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Allergy and Infectious Diseases; National Cancer Institute; National Institutes of Health; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology; University of Notre Dame; Massachusetts Institute of Technology; Massachusetts General Hospital; Canadian Institutes of Health Research; Mike and Josie Harper Cancer Research Institute; National Institute of General Medical Sciences; Cancer Research Institute","keywords":"Superantigen; T-cell receptor; Receptor; T cell; Biology; Cell biology; CD8; Molecular biology; Antigen; Immunology; Genetics; Immune system","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001122574,0.000226965,0.0002598193,0.00005349541,0.0001253791,0.0003490876,0.0001706863,0.0003882317,0.00266799],"category_scores_gemma":[0.0001682074,0.0001241568,0.000303989,0.00007564008,0.0001378972,0.0001930366,0.0001512773,0.0004064979,0.0006020944],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002996417,"about_ca_system_score_gemma":0.000225731,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004798327,"about_ca_topic_score_gemma":0.0007936604,"domain_scores_codex":[0.9998062,0.00003310584,0.000008934498,0.00002616201,0.00008712798,0.00003845006],"domain_scores_gemma":[0.9999424,0.00001357494,0.000009561113,0.00001195678,0.00001059788,0.00001192433],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001003997,0.00004953881,0.0009751106,0.0000405431,0.00001784489,0.00007261705,0.0000127011,0.0004277858,0.9964652,0.0002817485,0.0001571818,0.001399394],"study_design_scores_gemma":[0.0000824899,0.000995671,0.0200564,0.00001613006,0.00004833051,0.0007031636,0.0001139471,0.01529333,0.9515624,0.0003703126,0.01074433,0.00001349354],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993799,0.0005388728,0.001665801,0.000111323,0.00003705256,0.00001949974,0.0001713502,0.00004282264,0.003614246],"genre_scores_gemma":[0.9966814,0.000173868,0.0009470078,0.0001084824,0.000007469807,0.00001121171,0.00047895,0.000009201487,0.001582369],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00266799,"threshold_uncertainty_score":0.008925319,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0630897780997931,"score_gpt":0.3695588606609704,"score_spread":0.3064690825611773,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}