{"id":"W4400911972","doi":"10.20944/preprints202407.1712.v1","title":"Oligonucleotide Therapies for Facioscapulohumeral Muscular Dystrophy: Current Preclinical Landscape","year":2024,"lang":"en","type":"preprint","venue":"Preprints.org","topic":"Muscle Physiology and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"University of Alberta","keywords":"Facioscapulohumeral muscular dystrophy; Medicine; Epigenetics; Myopathy; Muscular dystrophy; Bioinformatics; Exon skipping; Disease; Gene; Biology; Genetics; Pathology; Internal medicine; Exon; Alternative splicing","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002073193,0.0008132325,0.001079897,0.001010712,0.0002694917,0.001434619,0.0007243197,0.001386344,0.004809333],"category_scores_gemma":[0.001441972,0.0002437389,0.0007371636,0.0005299708,0.0006352179,0.001299143,0.0006969825,0.002345314,0.001999824],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005452912,"about_ca_system_score_gemma":0.0009496925,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003233209,"about_ca_topic_score_gemma":0.0006779744,"domain_scores_codex":[0.9995436,0.0001559545,0.00004204534,0.000062599,0.0001484292,0.00004726861],"domain_scores_gemma":[0.999337,0.0003809918,0.00006762303,0.00003360954,0.0001245712,0.00005605418],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00138455,0.00117646,0.0003574275,0.01258818,0.0002281625,0.0003655289,0.000272358,0.001079585,0.05960363,0.01387118,0.01646459,0.8926083],"study_design_scores_gemma":[0.0006198548,0.00793536,0.001551525,0.005491306,0.0005212652,0.001543691,0.0002200167,0.0007292166,0.03755673,0.01011257,0.933641,0.00007743602],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.008956456,0.9706827,0.006897406,0.003098018,0.0008422164,0.0002231192,0.0003674975,0.0002364949,0.008696025],"genre_scores_gemma":[0.03057268,0.9538335,0.007995795,0.002021735,0.0006473877,0.0004106057,0.0008715306,0.00007649085,0.003570325],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004809333,"threshold_uncertainty_score":0.01608878,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09087840109527534,"score_gpt":0.3828456920692383,"score_spread":0.291967290973963,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}