{"id":"W4400914168","doi":"10.1038/s41467-024-50511-w","title":"The molecular basis underlying T cell specificity towards citrullinated epitopes presented by HLA-DR4","year":2024,"lang":"en","type":"article","venue":"Nature Communications","topic":"Rheumatoid Arthritis Research and Therapies","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"National Health and Medical Research Council; Medical Research Council; Australian Synchrotron","keywords":"Epitope; T-cell receptor; Human leukocyte antigen; Citrullination; Biology; T cell; Antigen; Immunology; Molecular biology; Computational biology; Genetics; Immune system; Citrulline","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001030362,0.0001161293,0.00007915427,0.0001008209,0.00007055774,0.0001887805,0.0001951422,0.000244999,0.001702974],"category_scores_gemma":[0.000158498,0.0000840862,0.00007919488,0.00006099821,0.0001488646,0.000121952,0.0001354053,0.0001970997,0.000317755],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001164293,"about_ca_system_score_gemma":0.00006949486,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002532539,"about_ca_topic_score_gemma":0.0001969945,"domain_scores_codex":[0.9999218,0.00001907314,0.000005270701,0.00001721521,0.00001148122,0.00002522276],"domain_scores_gemma":[0.9999243,0.00002052127,0.00002038057,0.000008807514,0.00000927533,0.00001667494],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001510478,0.000008780474,0.002767563,0.00002179093,0.000004339078,0.0001712932,0.00002142583,0.0001805018,0.9950384,0.0001773212,0.00002256291,0.001434825],"study_design_scores_gemma":[0.0001163262,0.001248504,0.1110909,0.00004322841,0.00006600402,0.005260664,0.0002919273,0.009592937,0.8667763,0.001593155,0.003898392,0.00002158544],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977017,0.0004086536,0.0008450966,0.00003566052,0.00000407803,0.0000047692,0.00002898726,0.00001077455,0.0009603892],"genre_scores_gemma":[0.9993838,0.0000835613,0.0002277551,0.00001606143,0.000002713419,0.000002237624,0.00002960998,0.000001594729,0.0002527005],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001702974,"threshold_uncertainty_score":0.005697012,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02822907931506776,"score_gpt":0.3414980996039402,"score_spread":0.3132690202888724,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}