{"id":"W4400936969","doi":"10.1101/2024.07.24.24310935","title":"Prospective Registration of Trials: Where we are, why, and how we could get better","year":2024,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Ethics in Clinical Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Impact","funders":"","keywords":"Medicine; Prospective cohort study; Clinical trial; Trial registration; Randomized controlled trial; MEDLINE; Internal medicine; Physical therapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch"],"consensus_categories":["metaresearch"],"category_scores_codex":[0.820282,0.002522225,0.01201961,0.01421778,0.006485168,0.03549524,0.008633826,0.01696648,0.01085999],"category_scores_gemma":[0.9244198,0.00544975,0.008680765,0.02416301,0.02776057,0.07400081,0.01990451,0.02551369,0.006718326],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.01216765,"about_ca_system_score_gemma":0.0721131,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002529558,"about_ca_topic_score_gemma":0.002679255,"domain_scores_codex":[0.07709069,0.7350331,0.1385888,0.0119176,0.03483711,0.002532684],"domain_scores_gemma":[0.02603041,0.6773017,0.1421531,0.1014392,0.04743825,0.005637305],"domain_codex":"methods","domain_gemma":"reproducibility","domain_candidate":"reproducibility","domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.007256269,0.0006957337,0.04927075,0.1164909,0.005848784,0.0008589452,0.02462875,0.002289434,0.002050297,0.1188785,0.1241699,0.5475618],"study_design_scores_gemma":[0.007390643,0.00327535,0.02871764,0.2618781,0.004797844,0.002363123,0.01182416,0.005986094,0.003913043,0.2673765,0.4007704,0.001707222],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.01582526,0.1749239,0.1436027,0.6146432,0.02082699,0.01357028,0.002714738,0.001328034,0.01256492],"genre_scores_gemma":[0.2317574,0.1033778,0.4172223,0.1714554,0.02606892,0.04067044,0.003636759,0.001798633,0.004012394],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.179718,"threshold_uncertainty_score":0.2216243,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.433489932986545,"score_gpt":0.5324767478930931,"score_spread":0.09898681490654804,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}