{"id":"W4400936970","doi":"10.1101/2024.07.24.24310923","title":"Uncovering the multivariate genetic architecture of frailty with genomic structural equation modelling","year":2024,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Frailty in Older Adults","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Nova Scotia Health Authority; Dalhousie University","funders":"Wellcome Trust","keywords":"Genetic architecture; Etiology; Genome-wide association study; Multivariate statistics; Genetic association; Population; Gerontology; Biology; Medicine; Genetics; Genotype; Computer science; Machine learning; Single-nucleotide polymorphism; Pathology; Gene; Environmental health; Quantitative trait locus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00727176,0.001124237,0.0009949233,0.002035999,0.000604171,0.001764493,0.0009458254,0.0007797947,0.002737463],"category_scores_gemma":[0.01805429,0.000559771,0.002233424,0.002207064,0.001011639,0.0007681301,0.001908776,0.002256824,0.00031714],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008355169,"about_ca_system_score_gemma":0.001446719,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0177965,"about_ca_topic_score_gemma":0.01507791,"domain_scores_codex":[0.9971545,0.002041491,0.0000723534,0.0004735572,0.0001145788,0.0001434676],"domain_scores_gemma":[0.9914019,0.006804648,0.0006517021,0.0007455117,0.0001887503,0.0002075485],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0004938216,0.0002695801,0.6839174,0.0002184211,0.005272579,0.0006725706,0.0008955041,0.1924782,0.001908837,0.0387999,0.006026507,0.06904662],"study_design_scores_gemma":[0.0001225346,0.0001540784,0.1303601,0.0001451635,0.0009901933,0.0002493209,0.000281834,0.7106408,0.0003835226,0.1535485,0.003040029,0.00008374767],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6337613,0.001716573,0.3536693,0.00433779,0.00010434,0.0001178023,0.003936922,0.0007152158,0.001640617],"genre_scores_gemma":[0.9531768,0.000504921,0.0434087,0.0002340637,0.00008404136,0.0001014885,0.001884801,0.00006444744,0.0005405962],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0177965,"threshold_uncertainty_score":0.03845721,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0397887302102326,"score_gpt":0.2791093288307905,"score_spread":0.2393205986205579,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}