{"id":"W4400942540","doi":"10.3390/ijms25158046","title":"Protective Effects of Hepatocyte Stress Defenders, Nrf1 and Nrf2, against MASLD Progression","year":2024,"lang":"en","type":"article","venue":"International Journal of Molecular Sciences","topic":"Liver Disease Diagnosis and Treatment","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"Canadian Institutes of Health Research","keywords":"Hepatocyte; Oxidative stress; Chemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002344537,0.0003580773,0.0003721543,0.0002381797,0.0001689159,0.0002016311,0.0001451133,0.0002811393,0.00152437],"category_scores_gemma":[0.0001280231,0.0001087513,0.0002255623,0.00008920486,0.0001967668,0.0003747615,0.0002257913,0.0004120986,0.0001996139],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001333757,"about_ca_system_score_gemma":0.0002062826,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002564642,"about_ca_topic_score_gemma":0.0007536537,"domain_scores_codex":[0.999895,0.00001811075,0.0000101939,0.00002676111,0.00001704011,0.00003280569],"domain_scores_gemma":[0.9998938,0.000006911765,0.00002951494,0.00001090058,0.00001929704,0.00003954797],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001154616,0.0001092267,0.0006651827,0.0001179761,0.00001685696,0.00004594102,0.00002968136,0.00005164061,0.9942151,0.0001184701,0.00008603278,0.003389336],"study_design_scores_gemma":[0.0001218611,0.003428729,0.01889078,0.00003667443,0.00009478792,0.0003990585,0.0001611579,0.0007055392,0.9710779,0.0002111394,0.004854662,0.00001763714],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934154,0.003374057,0.001432816,0.0002052838,0.00004633002,0.00002618687,0.0003400797,0.0000755092,0.0010844],"genre_scores_gemma":[0.9940579,0.001554158,0.001169217,0.00009636667,0.00001498108,0.00004502813,0.0003935063,0.00001114332,0.002657841],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00152437,"threshold_uncertainty_score":0.005099475,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01010626956451878,"score_gpt":0.3121290715068669,"score_spread":0.3020228019423481,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}