{"id":"W4400943407","doi":"10.1038/s42003-024-06584-w","title":"A ligand discovery toolbox for the WWE domain family of human E3 ligases","year":2024,"lang":"en","type":"article","venue":"Communications Biology","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium; Princess Margaret Cancer Centre; University of Toronto","funders":"National Institute of General Medical Sciences; Canadian Institutes of Health Research; Office of Science; Genentech; Ontario Genomics Institute; European Federation of Pharmaceutical Industries and Associations; Merck KGaA; National Institutes of Health; Ontario Genomics; Office of Research Infrastructure Programs, National Institutes of Health; Genome Canada; Argonne National Laboratory; European Commission; U.S. Department of Energy; McGill University; Bayer; Pfizer; Bristol-Myers Squibb","keywords":"Ubiquitin ligase; Computational biology; Ubiquitin; DNA ligase; Proteolysis; Drug discovery; Chemistry; Biology; Biochemistry; Cell biology; DNA; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007894972,0.001032418,0.0006970805,0.0008510489,0.0002241771,0.0007372497,0.0006898837,0.0005429493,0.005572469],"category_scores_gemma":[0.0004111549,0.0004118928,0.0005347044,0.0004502729,0.0002802895,0.0005544588,0.0007950375,0.0006600957,0.003354277],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004898975,"about_ca_system_score_gemma":0.0003869281,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002747717,"about_ca_topic_score_gemma":0.0004048856,"domain_scores_codex":[0.9997603,0.00004153867,0.00001967755,0.00005191933,0.00009983995,0.00002672703],"domain_scores_gemma":[0.9998627,0.00004868583,0.00002065963,0.00002260421,0.00002118622,0.00002422664],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008104091,0.0003186267,0.001143517,0.001029102,0.0001545566,0.0007121545,0.0001031822,0.01795267,0.703844,0.01753138,0.01180837,0.244592],"study_design_scores_gemma":[0.0004498901,0.000676425,0.00111507,0.0001313199,0.0001056257,0.001420917,0.00004769492,0.08814513,0.6570129,0.009418277,0.2413887,0.00008793295],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.096427,0.0107319,0.8230594,0.001171872,0.0001700337,0.0008220485,0.006936647,0.04190205,0.01877917],"genre_scores_gemma":[0.3599313,0.01561396,0.5875136,0.0006131324,0.0001047318,0.001806451,0.01053025,0.001058424,0.02282798],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.005572469,"threshold_uncertainty_score":0.01864177,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03732267077969285,"score_gpt":0.3389847918655572,"score_spread":0.3016621210858644,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}