{"id":"W4400948155","doi":"10.1038/s44319-024-00206-6","title":"BCL-2 and BOK regulate apoptosis by interaction of their C-terminal transmembrane domains","year":2024,"lang":"en","type":"article","venue":"EMBO Reports","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Sunnybrook Health Science Centre","funders":"Canadian Institutes of Health Research; Stuttgart Center for Simulation Science, Universität Stuttgart; Bundesministerium für Bildung und Forschung; Deutsche Forschungsgemeinschaft; Singapore Institute of Manufacturing Technology; Robert Bosch Stiftung","keywords":"Apoptosis; Cell biology; Transmembrane domain; Endoplasmic reticulum; Effector; Protein–protein interaction; Transmembrane protein; Chemistry; Inhibitor of apoptosis domain; HEK 293 cells; Biology; Biochemistry; Programmed cell death; Caspase; Membrane; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001439178,0.0002629877,0.0001520957,0.0001452692,0.0001649817,0.0004061547,0.0002608725,0.0002333916,0.001146947],"category_scores_gemma":[0.0001767396,0.00009890069,0.0001061938,0.0001794715,0.0002523577,0.000382938,0.0003087131,0.0003865174,0.0004819616],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004080192,"about_ca_system_score_gemma":0.0001487451,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002493564,"about_ca_topic_score_gemma":0.0002793036,"domain_scores_codex":[0.9998486,0.00003253306,0.000008437971,0.00002488933,0.00005459409,0.00003092778],"domain_scores_gemma":[0.9999301,0.00001123573,0.00002203457,0.000007253671,0.00001144159,0.00001790739],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001584458,0.00002124652,0.0003268362,0.00005982347,0.000005013876,0.00007021038,0.0000149398,0.0002062502,0.9936811,0.002029583,0.0001263899,0.003300175],"study_design_scores_gemma":[0.0000647624,0.0001498051,0.004223343,0.00001146881,0.00001361514,0.0006253902,0.00005436985,0.004281723,0.9638662,0.001213482,0.02548204,0.00001374391],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9476667,0.01174275,0.02912421,0.0007143174,0.000095333,0.00005866903,0.0005188297,0.0003625711,0.009716644],"genre_scores_gemma":[0.9864333,0.002610414,0.005758781,0.000103618,0.00001992827,0.0000401925,0.0003429215,0.00002791596,0.004662977],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001146947,"threshold_uncertainty_score":0.00383693,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007143641409142292,"score_gpt":0.2455564736382523,"score_spread":0.23841283222911,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}