{"id":"W4400948347","doi":"10.2337/db23-0802","title":"GAS6 and AXL Promote Insulin Resistance by Rewiring Insulin Signaling and Increasing Insulin Receptor Trafficking to Endosomes","year":2024,"lang":"en","type":"article","venue":"Diabetes","topic":"Phagocytosis and Immune Regulation","field":"Immunology and Microbiology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Université de Montréal; Montreal Clinical Research Institute","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Canada Research Chairs; Diabetes Canada","keywords":"GAS6; Insulin resistance; Insulin receptor; MERTK; Insulin; Endocrinology; Internal medicine; Biology; Receptor; Signal transduction; Cell biology; Receptor tyrosine kinase; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001612757,0.0003630297,0.0002247817,0.0002580354,0.0001426076,0.0003719146,0.0002272277,0.0004561252,0.002437047],"category_scores_gemma":[0.00008174562,0.0001210867,0.0003512998,0.0001182496,0.0002935387,0.0003272693,0.0003700658,0.00079729,0.0004803341],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003145855,"about_ca_system_score_gemma":0.0001752058,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002614798,"about_ca_topic_score_gemma":0.0005299819,"domain_scores_codex":[0.9998136,0.00004214897,0.00001191518,0.00002412065,0.00005540531,0.00005279027],"domain_scores_gemma":[0.9999028,0.000009110467,0.00002762883,0.000007746655,0.000006914992,0.00004573484],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008780128,0.0001027827,0.000353683,0.00007784947,0.00001230655,0.00009694263,0.00001743882,0.0001091847,0.9939957,0.0005148052,0.0002191027,0.003622147],"study_design_scores_gemma":[0.0001648155,0.001797789,0.0069441,0.00001700061,0.00003246546,0.0005047965,0.00008964369,0.001718317,0.9796601,0.0003124656,0.008748268,0.00001022299],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9892033,0.003664922,0.003109719,0.0006429747,0.0001078637,0.00002431936,0.0002976695,0.0001547348,0.00279452],"genre_scores_gemma":[0.9899684,0.001406877,0.002963339,0.0002029803,0.00003600819,0.0000306834,0.0003615221,0.00003209857,0.004998068],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002437047,"threshold_uncertainty_score":0.008152783,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00785379115968416,"score_gpt":0.2192153916500216,"score_spread":0.2113616004903375,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}