{"id":"W4400948953","doi":"10.1038/s41586-024-07718-0","title":"SMYD5 methylation of rpL40 links ribosomal output to gastric cancer","year":2024,"lang":"en","type":"article","venue":"Nature","topic":"RNA modifications and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":41,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"DOD Peer Reviewed Cancer Research Program; Eunice Kennedy Shriver National Institute of Child Health and Human Development; Cancer Prevention and Research Institute of Texas; National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences; National Institute for International Education; Fonds de Recherche du Québec - Santé; National Science Foundation; Canadian Institutes of Health Research; National Cancer Institute; National Institutes of Health; Vetenskapsrådet; Division of Chemistry; Cancerfonden","keywords":"Methylation; Cancer; Ribosomal RNA; Biology; DNA methylation; Computational biology; Cancer research; Genetics; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001892581,0.0002520903,0.000143689,0.0002365457,0.0001707306,0.000375683,0.0002163202,0.000306646,0.003195685],"category_scores_gemma":[0.0002613996,0.0002314861,0.0002360285,0.0001347782,0.0002788858,0.0001850173,0.0002867876,0.0003693177,0.0004429234],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004174419,"about_ca_system_score_gemma":0.0002135615,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001263715,"about_ca_topic_score_gemma":0.002044332,"domain_scores_codex":[0.9999025,0.00001186206,0.000006081054,0.00002643773,0.00002142598,0.00003172283],"domain_scores_gemma":[0.9998899,0.00001189141,0.00004454837,0.00001531481,0.00001146618,0.0000268794],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008724755,0.00002443117,0.006257587,0.00008079763,0.00004698622,0.0001698848,0.00003966569,0.0001713371,0.9835207,0.0005594466,0.0005334732,0.007723378],"study_design_scores_gemma":[0.00004235475,0.0004617662,0.09345484,0.0000190914,0.00006867444,0.0005709626,0.0001465703,0.001434814,0.8929579,0.0007784792,0.01004855,0.00001594984],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9913638,0.003370456,0.00176704,0.0004236788,0.00009607434,0.000008999826,0.000595023,0.0002164078,0.002158602],"genre_scores_gemma":[0.9972703,0.000341645,0.0003326803,0.00007645773,0.000009367185,0.000004425652,0.0002518395,0.00001792558,0.001695324],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003195685,"threshold_uncertainty_score":0.01069057,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009938142264954177,"score_gpt":0.3017474897292801,"score_spread":0.291809347464326,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}