{"id":"W4400952608","doi":"10.1161/atvb.44.suppl_1.3067","title":"Abstract 3067: Chronic Knockout Of The ETS Transcription Factor ERG Promotes Loss Of Endothelial Cell Identity And Endothelial Cell Dysfunction In An Aortic Endothelial Cell Model Relevant For Atherosclerosis","year":2024,"lang":"en","type":"article","venue":"Arteriosclerosis Thrombosis and Vascular Biology","topic":"Atherosclerosis and Cardiovascular Diseases","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; University Health Network","funders":"","keywords":"Endothelial stem cell; Endothelial dysfunction; Transcription factor; Cell; Endothelium; Medicine; Cell biology; Biology; Internal medicine; Genetics; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003143765,0.0004870431,0.0005782761,0.0004370081,0.0003583126,0.000435593,0.0002939471,0.0005818473,0.005652303],"category_scores_gemma":[0.0001344708,0.0002414106,0.0004879592,0.0003506473,0.0004641099,0.000250616,0.000336051,0.001436465,0.001672821],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002717667,"about_ca_system_score_gemma":0.0002363559,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000931675,"about_ca_topic_score_gemma":0.001242268,"domain_scores_codex":[0.9994748,0.00004208938,0.00005799982,0.0001522393,0.000167006,0.0001058114],"domain_scores_gemma":[0.9996753,0.00003652966,0.00007871805,0.00004366108,0.00004463258,0.0001210574],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001737011,0.00003667036,0.0001929636,0.00004756521,0.000008139458,0.00005510767,0.00001482856,0.00002821076,0.9986603,0.00005860627,0.0001328127,0.000591071],"study_design_scores_gemma":[0.00005003108,0.0002633237,0.01150396,0.0000207572,0.00004757474,0.0004080847,0.00007577782,0.001002871,0.9830782,0.00009523294,0.003441591,0.00001263044],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9732437,0.001798175,0.01281887,0.0004014053,0.0002269868,0.00006921076,0.007472952,0.0005240245,0.003444765],"genre_scores_gemma":[0.9692339,0.001073923,0.005290409,0.0003816919,0.00004211274,0.0001880411,0.008541483,0.0002201404,0.01502842],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005652303,"threshold_uncertainty_score":0.01890886,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02899372346158039,"score_gpt":0.260692155310938,"score_spread":0.2316984318493577,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}