{"id":"W4400952966","doi":"10.1289/ehp13667","title":"Investigation of Peroxisome Proliferator-Activated Receptor Genes as Requirements for Visual Startle Response Hyperactivity in Larval Zebrafish Exposed to Structurally Similar Per- and Polyfluoroalkyl Substances (PFAS)","year":2024,"lang":"en","type":"article","venue":"Environmental Health Perspectives","topic":"Per- and polyfluoroalkyl substances research","field":"Environmental Science","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institut de Recherche et de Développement en Agroenvironnement","funders":"Office of Research and Development; U.S. Environmental Protection Agency","keywords":"Zebrafish; Gene; Peroxisome proliferator; Receptor; Larva; Peroxisome proliferator-activated receptor; Biology; Endocrinology; Internal medicine; Chemistry; Medicine; Genetics; Ecology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0009414628,0.0003355326,0.0004031807,0.0002023529,0.0002839495,0.00007670143,0.0002142143,0.0001172573,0.0009805908],"category_scores_gemma":[0.00007844269,0.000324313,0.00007845581,0.0003562858,0.0004839071,0.000927837,0.0001569017,0.0002778272,0.00006504222],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001590961,"about_ca_system_score_gemma":0.0001473039,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004089874,"about_ca_topic_score_gemma":0.0004050168,"domain_scores_codex":[0.9966975,0.0005179364,0.0004929752,0.0009208,0.000698043,0.0006727711],"domain_scores_gemma":[0.9989493,0.0002846652,0.0001151937,0.0002346887,0.000008958571,0.0004071575],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001869952,0.0001441046,0.06547114,0.00008785759,0.00002704863,0.00000505424,0.01601572,0.00003492221,0.8994709,0.00002250746,0.0001515331,0.0166993],"study_design_scores_gemma":[0.001618507,0.00367174,0.4539083,0.0002016979,0.00001325303,0.00001448915,0.02446472,0.0008222865,0.5086283,0.0003731255,0.005569892,0.0007136571],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9846579,0.01108516,0.00002137323,0.002159795,0.0001313234,0.001570626,0.0002826427,0.00005279939,0.00003837773],"genre_scores_gemma":[0.9964849,0.000990286,0.001720412,0.0001900622,0.0000723853,0.0001899375,0.00004146321,0.00005083812,0.0002596889],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3908425,"threshold_uncertainty_score":0.9999326,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02915130000739372,"score_gpt":0.3283423253215605,"score_spread":0.2991910253141667,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}