{"id":"W4400953077","doi":"10.1161/atvb.44.suppl_1.1041","title":"Abstract 1041: Loss Of The ETS Transcription Factor ERG Disrupts Fate-defining Programs In The Aortic Endothelium And Promotes Expansion Of Endothelial Lineage Cells In Atherosclerotic Plaque","year":2024,"lang":"en","type":"article","venue":"Arteriosclerosis Thrombosis and Vascular Biology","topic":"Atherosclerosis and Cardiovascular Diseases","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto General Hospital","funders":"","keywords":"Transcription factor; Endothelium; Cell biology; ETS transcription factor family; Lineage (genetic); Biology; Medicine; Immunology; Internal medicine; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001708803,0.0005225026,0.0003468475,0.0003220988,0.000236617,0.0003734818,0.0002802687,0.0004568362,0.005869984],"category_scores_gemma":[0.0001020653,0.0002089498,0.0003386369,0.0001903422,0.000420792,0.0002915198,0.0002967669,0.001221577,0.00157265],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003439573,"about_ca_system_score_gemma":0.0002666947,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006680366,"about_ca_topic_score_gemma":0.0008681034,"domain_scores_codex":[0.9997543,0.00002469718,0.00002680198,0.0000575297,0.00007584541,0.00006096646],"domain_scores_gemma":[0.9998234,0.00002050638,0.0000560333,0.00001950536,0.00001308503,0.00006745338],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002426152,0.00005055173,0.0002005486,0.00002955018,0.000004962953,0.00006376622,0.000008608209,0.00003808091,0.9984601,0.00006305049,0.00008391933,0.0007543915],"study_design_scores_gemma":[0.00003977254,0.0003175355,0.007967314,0.00001095206,0.00002335337,0.0005130834,0.0000388802,0.0006159617,0.988313,0.00004990075,0.002105103,0.000005103801],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9901921,0.0009112402,0.003835764,0.0002154514,0.00007805575,0.00003028873,0.001894667,0.0001914257,0.002651184],"genre_scores_gemma":[0.9791722,0.0006808387,0.001932823,0.0001274915,0.00002039706,0.00005357724,0.002454422,0.0001161528,0.01544214],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005869984,"threshold_uncertainty_score":0.01963705,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03130780012125823,"score_gpt":0.2518141407356076,"score_spread":0.2205063406143494,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}