{"id":"W4400963657","doi":"10.3389/fneur.2024.1440678","title":"Efficacy of cannabinoids compared to the current standard treatments on symptom relief in persons with multiple sclerosis (CANSEP trial): study protocol for a randomized clinical trial","year":2024,"lang":"en","type":"article","venue":"Frontiers in Neurology","topic":"Cannabis and Cannabinoid Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université du Québec à Montréal; Université de Montréal; Multiple Sclerosis Society of Canada; Centre Hospitalier de l’Université de Montréal","funders":"Canadian Institutes of Health Research","keywords":"Medicine; Randomized controlled trial; Placebo; Spasticity; Clinical trial; Physical therapy; Randomization; Multiple sclerosis; Internal medicine; Psychiatry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.02419697,0.007153033,0.01178527,0.001955511,0.00313358,0.00362089,0.004092147,0.007917053,0.06700785],"category_scores_gemma":[0.02211463,0.002956439,0.00474834,0.002706609,0.003870073,0.00338233,0.002039671,0.006741597,0.0109509],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003527402,"about_ca_system_score_gemma":0.01261785,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001830738,"about_ca_topic_score_gemma":0.003445568,"domain_scores_codex":[0.985578,0.008564143,0.001450384,0.001389462,0.001395375,0.001622587],"domain_scores_gemma":[0.9900601,0.002597039,0.002125883,0.001380941,0.002017496,0.001818522],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"not_applicable","study_design_scores_codex":[0.9695677,0.008577719,0.0002752026,0.005289639,0.000725068,0.00008253967,0.0001069884,0.000577609,0.0008943261,0.00104259,0.005116732,0.00774392],"study_design_scores_gemma":[0.9714832,0.01849742,0.0005653597,0.0005131743,0.0003600426,0.00002020199,0.00003229738,0.0005586781,0.0002155116,0.0006938531,0.007023063,0.00003712414],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"protocol","genre_gemma":"protocol","genre_scores_codex":[0.004718668,0.000476454,0.000944049,0.0002829527,0.0004852113,0.9903992,0.001437644,0.0001146111,0.001141235],"genre_scores_gemma":[0.004063349,0.0002626606,0.001525691,0.0002638652,0.0001119392,0.992785,0.0002505517,0.000008124217,0.0007289283],"genre_candidate":"protocol","genre_consensus":"protocol","teacher_disagreement_score":0.06700785,"threshold_uncertainty_score":0.2241635,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07330543765969705,"score_gpt":0.4116609032113877,"score_spread":0.3383554655516906,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}