{"id":"W4400965224","doi":"10.1101/2024.07.22.604624","title":"Interplay of Light, Melatonin, and Circadian Genes in Skin Pigmentation Regulation","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"melanin and skin pigmentation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hotchkiss Brain Institute; Alberta Children's Hospital","funders":"","keywords":"Melatonin; Circadian rhythm; Biology; Gene; Neuroscience; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006146094,0.0002118314,0.0001730682,0.0001619984,0.0001309913,0.0002850132,0.00009884714,0.0001387001,0.00140815],"category_scores_gemma":[0.00004237322,0.00008685763,0.0001717753,0.00008969413,0.0001236031,0.0001748515,0.0001415962,0.0003515237,0.0001859116],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003590009,"about_ca_system_score_gemma":0.0001553104,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009502858,"about_ca_topic_score_gemma":0.001338262,"domain_scores_codex":[0.9999434,0.000006838567,0.000004339998,0.00002049047,0.00001136378,0.00001370644],"domain_scores_gemma":[0.999921,0.00000787418,0.00002231116,0.000005287311,0.00001670261,0.00002693494],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005198986,0.000004268133,0.00028242,0.00002169202,0.000002773281,0.00001725748,0.000004748152,0.00001939644,0.9986631,0.00005046412,0.00003384274,0.0008481279],"study_design_scores_gemma":[0.00002458306,0.0002321433,0.1067365,0.00001844645,0.00004055319,0.0002281073,0.00008523225,0.001455265,0.8849257,0.000221841,0.006016837,0.00001480791],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9853672,0.006344449,0.004175547,0.0002971427,0.00006203286,0.00002950854,0.0006101877,0.0001194327,0.00299458],"genre_scores_gemma":[0.9916955,0.001407776,0.001615189,0.0001159179,0.00003169506,0.00002550968,0.000397682,0.00003411932,0.00467669],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00140815,"threshold_uncertainty_score":0.004710734,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006663462295589472,"score_gpt":0.233508200967414,"score_spread":0.2268447386718245,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}