{"id":"W4400965414","doi":"10.1101/2024.07.22.604665","title":"Cleavage region organizes the structural architecture of the B2 SINE ribozyme","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; University of Alberta; University of Lethbridge","funders":"","keywords":"Ribozyme; RNA; Biology; Chromatin; Nucleic acid structure; Non-coding RNA; Circular RNA; Mammalian CPEB3 ribozyme; Cleavage (geology); Computational biology; Cell biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009567202,0.0001627898,0.0001599145,0.0001765407,0.0001591714,0.0003944438,0.0001565395,0.0002576635,0.0005816704],"category_scores_gemma":[0.0002198787,0.0001893442,0.0001614248,0.0001106292,0.0002647369,0.0001772489,0.0001284718,0.0002810733,0.000297356],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002422176,"about_ca_system_score_gemma":0.0001354404,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004403098,"about_ca_topic_score_gemma":0.0003407971,"domain_scores_codex":[0.9999372,0.000009534547,0.000003581967,0.00002557097,0.00001476837,0.000009344142],"domain_scores_gemma":[0.9998692,0.00003046992,0.00003184845,0.00001903598,0.00001921227,0.00003028111],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005962077,0.00001294776,0.00140213,0.00001393141,0.000005940031,0.00004988833,0.00002348757,0.004470678,0.9918728,0.00080783,0.00002948069,0.001251244],"study_design_scores_gemma":[0.00002166704,0.0004315658,0.0225302,0.000008933454,0.00001929633,0.0003356846,0.00008192847,0.1068186,0.865438,0.002863865,0.001426162,0.00002411076],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9876879,0.0001357405,0.01094515,0.00002032628,0.000004821883,0.000007454729,0.00009587679,0.00007230716,0.001030462],"genre_scores_gemma":[0.9972532,0.00002520222,0.002337019,0.000008520368,0.000001782867,0.000004646837,0.0001190576,0.00001624853,0.000234364],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005816704,"threshold_uncertainty_score":0.001945913,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007738377999385791,"score_gpt":0.2003723716270744,"score_spread":0.1926339936276886,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}