{"id":"W4400972522","doi":"10.2139/ssrn.4904689","title":"Detecting Homologous Recombination Deficiency for Breast Cancer Through Integrative Analysis of Genomic Data","year":2024,"lang":"en","type":"preprint","venue":"SSRN Electronic Journal","topic":"Genomic variations and chromosomal abnormalities","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institute of Cancer Research","funders":"","keywords":"Homologous recombination; Breast cancer; Recombination; Homologous chromosome; Computational biology; Genetics; Biology; Cancer; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008732665,0.0004349926,0.0006220351,0.00254395,0.0002168401,0.0006241127,0.000455703,0.0004782288,0.002844574],"category_scores_gemma":[0.001968688,0.0002511286,0.0004779969,0.002330764,0.0002364947,0.0003433974,0.0006208748,0.000534019,0.001034088],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002683334,"about_ca_system_score_gemma":0.0002622506,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004839266,"about_ca_topic_score_gemma":0.0008307426,"domain_scores_codex":[0.9993562,0.00009128549,0.00005432378,0.0002189161,0.0002157284,0.00006351565],"domain_scores_gemma":[0.998969,0.000513476,0.0002217924,0.0001443095,0.00007209892,0.00007951147],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0008872114,0.0001438607,0.0315857,0.000260554,0.0001847092,0.0009295981,0.0001626596,0.001530712,0.9031469,0.0009117241,0.0008017221,0.05945454],"study_design_scores_gemma":[0.0001929684,0.00074288,0.3062402,0.00005881927,0.0006500203,0.006824505,0.000462658,0.05616906,0.6120439,0.005312705,0.01122213,0.00008012712],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9326805,0.001297192,0.05303302,0.0002378276,0.00004439382,0.0001146036,0.007246035,0.002137473,0.003209015],"genre_scores_gemma":[0.9037665,0.0005386704,0.08193117,0.00007311863,0.00003450942,0.00005589362,0.01213127,0.0003941726,0.001074629],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002844574,"threshold_uncertainty_score":0.00951606,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01703971572497767,"score_gpt":0.2928288862969001,"score_spread":0.2757891705719225,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}