{"id":"W4400972670","doi":"10.1200/cci.23.00265","title":"Identification of Novel DNA Methylation Prognostic Biomarkers for AML With Normal Cytogenetics","year":2024,"lang":"en","type":"article","venue":"JCO Clinical Cancer Informatics","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"William Osler Health System","funders":"","keywords":"Cytogenetics; DNA methylation; Identification (biology); Computational biology; Medicine; Biology; Oncology; Genetics; Chromosome; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001164789,0.0001516143,0.0003643596,0.0001931184,0.00004774032,0.00005638962,0.0001551491,0.0001909384,0.0000302183],"category_scores_gemma":[0.0009295029,0.0001124247,0.000162972,0.0005283012,0.0002349492,0.00024643,0.00005298784,0.0003019007,0.00001827038],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000194392,"about_ca_system_score_gemma":0.001120853,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001340882,"about_ca_topic_score_gemma":0.00001464031,"domain_scores_codex":[0.9974619,0.00002369058,0.001548895,0.000164762,0.0005259066,0.0002748558],"domain_scores_gemma":[0.9976742,0.0009512317,0.0003253552,0.0003371819,0.0005527107,0.0001593069],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.009806917,0.001831124,0.1240276,0.03314579,0.005686495,0.00002709519,0.01130582,0.004138324,0.03374957,0.00502733,0.03443016,0.7368238],"study_design_scores_gemma":[0.009562361,0.003353299,0.04608714,0.001517904,0.001956534,0.00005994711,0.001525011,0.8538958,0.04697672,0.0001446344,0.03433593,0.0005847375],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.784122,0.0007704627,0.2082838,0.001539233,0.0007264743,0.003000158,0.0003990082,0.0001519424,0.001006922],"genre_scores_gemma":[0.9713777,0.0004207305,0.02662939,0.0003139864,0.0003530978,0.0002617103,0.0001744059,0.00004385939,0.0004251756],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8497574,"threshold_uncertainty_score":0.4584548,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09156657437258642,"score_gpt":0.4344966028089758,"score_spread":0.3429300284363894,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}