{"id":"W4400976325","doi":"10.3390/cancers16152650","title":"Genome-Wide Methylation Patterns in Primary Uveal Melanoma: Development of MethylSig-UM, an Epigenomic Prognostic Signature to Improve Patient Stratification","year":2024,"lang":"en","type":"article","venue":"Cancers","topic":"Ocular Oncology and Treatments","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"University of Pennsylvania","keywords":"Epigenomics; DNA methylation; Oncology; Metastasis; Proportional hazards model; Medicine; Methylation; Melanoma; Cohort; Internal medicine; Computational biology; Bioinformatics; Cancer; Biology; Cancer research; Gene; Gene expression; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0010136,0.0002798964,0.0003362725,0.0005977098,0.0001462564,0.0003129158,0.0002325318,0.0001874325,0.0004400778],"category_scores_gemma":[0.001480207,0.0001275285,0.000303208,0.0004881439,0.0001218286,0.0001521843,0.0003591793,0.0003074469,0.0001232571],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003250628,"about_ca_system_score_gemma":0.0003210041,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002072458,"about_ca_topic_score_gemma":0.004399589,"domain_scores_codex":[0.9997787,0.00008320847,0.00001104901,0.0000601892,0.00003763215,0.00002915209],"domain_scores_gemma":[0.9996954,0.00008176684,0.00007749448,0.00004833223,0.00005486065,0.00004228276],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002297688,0.0001372917,0.6391244,0.0001633542,0.0004429718,0.0001514494,0.0001826889,0.01620047,0.1268117,0.0004442876,0.00132544,0.2127182],"study_design_scores_gemma":[0.0000775283,0.001175678,0.6832532,0.00004713122,0.0003702025,0.0008887914,0.00009978755,0.2471606,0.06204978,0.00142853,0.003394281,0.00005455947],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9807094,0.0009289673,0.01615725,0.0001024872,0.000009488056,0.00005833669,0.001331141,0.0001560287,0.0005469258],"genre_scores_gemma":[0.9868205,0.0001906208,0.01171795,0.00003025615,0.000007985324,0.00003278341,0.0009570215,0.00001405955,0.0002287692],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002072458,"threshold_uncertainty_score":0.005360544,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01306153620387127,"score_gpt":0.2758910743374808,"score_spread":0.2628295381336095,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}