{"id":"W4400980549","doi":"10.3390/biom14080905","title":"Lithium Ions as Modulators of Complex Biological Processes: The Conundrum of Multiple Targets, Responsiveness and Non-Responsiveness, and the Potential to Prevent or Correct Dysregulation of Systems during Aging and in Disease","year":2024,"lang":"en","type":"review","venue":"Biomolecules","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Bone and Joint Health Institute; University of Calgary","funders":"","keywords":"Neuroscience; Lithium (medication); Disease; Ion channel; Medicine; Biology; Endocrinology; Internal medicine; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006341808,0.0002638806,0.0008167366,0.0003675781,0.0001910954,0.00006038757,0.000377274,0.00008323815,0.000001775439],"category_scores_gemma":[0.002368362,0.0001326254,0.00008921132,0.000982365,0.001904218,0.00006563072,0.000591992,0.000199134,6.87746e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001769055,"about_ca_system_score_gemma":0.0003588271,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004251768,"about_ca_topic_score_gemma":0.000006292576,"domain_scores_codex":[0.9966671,0.00155018,0.0005833523,0.0006299282,0.0003103225,0.0002590641],"domain_scores_gemma":[0.9973257,0.001913244,0.0003003736,0.0002573912,0.00009403922,0.0001092324],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004882594,0.0002993056,0.0003830642,0.0383843,0.00005685056,0.0004294663,0.0006044985,0.0001550266,0.9498188,0.0003152787,0.00001547287,0.004655324],"study_design_scores_gemma":[0.01128082,0.003874635,0.04442772,0.08232503,0.003669046,0.003016716,0.002835573,0.02251064,0.7795776,0.0005841734,0.04228441,0.003613639],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6602721,0.3369332,0.00001795212,0.0001942787,0.0001853108,0.002191466,0.0001940543,0.0000101054,0.000001562351],"genre_scores_gemma":[0.6366071,0.3631876,0.000002416212,0.00001826152,0.00001391094,0.0001153388,0.000001673132,0.00001470067,0.00003906125],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1702412,"threshold_uncertainty_score":0.7016171,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0694176621389185,"score_gpt":0.3749281071296459,"score_spread":0.3055104449907273,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}