{"id":"W4400982324","doi":"10.1002/cpt.3387","title":"PharmVar GeneFocus: <i>CYP2A6</i>","year":2024,"lang":"en","type":"review","venue":"Clinical Pharmacology & Therapeutics","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Centre for Addiction and Mental Health","funders":"National Human Genome Research Institute; National Institute on Drug Abuse; Canadian Institutes of Health Research; National Institutes of Health","keywords":"CYP2A6; Allele; Genetics; Biology; Genetic variation; Gene; Phenotype; Genotype; Locus (genetics); Computational biology; Genotype-phenotype distinction; Bioinformatics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006289533,0.000921969,0.001138941,0.003212165,0.0002693314,0.001606455,0.001155762,0.001149718,0.03594747],"category_scores_gemma":[0.001169451,0.0001665948,0.0006857622,0.004261412,0.0005209901,0.001475176,0.001107044,0.001900162,0.04059537],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005655934,"about_ca_system_score_gemma":0.001188995,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001063761,"about_ca_topic_score_gemma":0.001345274,"domain_scores_codex":[0.9996628,0.00006072791,0.00004526998,0.00005561339,0.0001297722,0.00004579775],"domain_scores_gemma":[0.9993368,0.0002033672,0.0001215344,0.00003763496,0.0001926455,0.0001080204],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001088144,0.00003710073,0.0001942964,0.008298022,0.0000427466,0.0001912969,0.00004000924,0.0001143424,0.002684758,0.004666996,0.2380598,0.7455618],"study_design_scores_gemma":[0.000006790783,0.00002042985,0.000310766,0.0006441649,0.00001434352,0.0004310448,0.000006570269,0.00001763948,0.0003113447,0.0005346861,0.9976967,0.00000557663],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0008953476,0.8994175,0.003542043,0.006095231,0.005566308,0.0002211745,0.005266708,0.001187289,0.0778084],"genre_scores_gemma":[0.004413918,0.9119911,0.005516138,0.006124929,0.003401106,0.000203652,0.01032294,0.0003622075,0.05766415],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.03594747,"threshold_uncertainty_score":0.1202562,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.5594046779091968,"score_gpt":0.6417700626406821,"score_spread":0.08236538473148536,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}