{"id":"W4400998146","doi":"10.1186/s12885-022-10427-4","title":"Pembrolizumab with platinum-based chemotherapy with or without epacadostat as first-line treatment for metastatic non-small cell lung cancer: a randomized, partially double-blind, placebo-controlled phase II study","year":2024,"lang":"en","type":"article","venue":"BMC Cancer","topic":"Tryptophan and brain disorders","field":"Neuroscience","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre intégré de santé et de services sociaux de la Montérégie-Centre; Santé Montérégie","funders":"Incyte","keywords":"Medicine; Surgical oncology; Pembrolizumab; Chemotherapy; Placebo; Oncology; Internal medicine; Lung cancer; Cancer; Immunotherapy; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003703565,0.0007898439,0.001638904,0.0002522475,0.0004354855,0.0002830798,0.0003176755,0.00007906396,0.0006276213],"category_scores_gemma":[0.00005789136,0.0004351985,0.000364033,0.0006283575,0.0002175561,0.0002018683,0.00002746549,0.0001977309,0.000008983494],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003805687,"about_ca_system_score_gemma":0.002724243,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001476515,"about_ca_topic_score_gemma":0.02824854,"domain_scores_codex":[0.9965231,0.000213529,0.0006588878,0.001253914,0.0005691925,0.0007813656],"domain_scores_gemma":[0.9973349,0.001500901,0.0003339338,0.0004755942,0.0001025603,0.000252115],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.968878,0.002809437,0.0002570194,0.0004351696,0.0006559373,0.00009415615,0.00426232,0.01881016,0.001168683,0.00002644046,0.000194701,0.002407997],"study_design_scores_gemma":[0.8185185,0.008696727,0.000002853506,0.0002952121,0.001273176,0.0000107497,0.0003328397,0.1390392,0.03023423,0.00001190981,0.00100569,0.0005789344],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9563207,0.00134716,0.01589097,0.0007741539,0.0002965367,0.02456311,0.000235335,0.0002749627,0.000297059],"genre_scores_gemma":[0.9589385,0.0003242193,0.001016194,0.0006657725,0.0001943236,0.03176119,0.00001670502,0.0001850008,0.006898101],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1503595,"threshold_uncertainty_score":0.99981,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04983675772780816,"score_gpt":0.3552285312866115,"score_spread":0.3053917735588033,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}