{"id":"W4400998795","doi":"10.1101/2024.07.24.604963","title":"Muscle stem cells in Duchenne muscular dystrophy exhibit molecular impairments and altered cell fate trajectories impacting regenerative capacity","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Muscle Physiology and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Neurological Institute and Hospital; McGill University","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Stem Cell Network","keywords":"Duchenne muscular dystrophy; Satellite; Muscular dystrophy; Physical medicine and rehabilitation; Medicine; Internal medicine; Engineering; Aerospace engineering","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001561155,0.0002190476,0.0003046406,0.0004426134,0.0002025168,0.000301578,0.00008972757,0.0002424258,0.001105644],"category_scores_gemma":[0.00009892399,0.0001309782,0.0001859275,0.0002309322,0.0002162187,0.0001243561,0.000197363,0.0002915532,0.0003119688],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002217572,"about_ca_system_score_gemma":0.0001347733,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008038338,"about_ca_topic_score_gemma":0.001620564,"domain_scores_codex":[0.9998578,0.00001371641,0.00001777139,0.00003994347,0.0000481695,0.00002264607],"domain_scores_gemma":[0.9998806,0.00001567587,0.00004156451,0.00001255169,0.00001811389,0.00003150647],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007742385,0.00001164485,0.00277261,0.00004906897,0.00000762135,0.0001256971,0.00007044253,0.00007895022,0.9952776,0.00003606705,0.00003818089,0.001454641],"study_design_scores_gemma":[0.00001548749,0.0005297521,0.2900621,0.00005148292,0.00005279586,0.001614999,0.0007078065,0.002373499,0.6997426,0.0002258975,0.004607534,0.00001613749],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968348,0.0008984316,0.001067122,0.0000294677,0.000009229246,0.000008840291,0.0006351345,0.00006752875,0.00044942],"genre_scores_gemma":[0.9946353,0.0006034012,0.001446065,0.00005016668,0.00000444249,0.00002769213,0.001261252,0.00001853313,0.001953212],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001105644,"threshold_uncertainty_score":0.003698707,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00926795410345094,"score_gpt":0.2066249065851633,"score_spread":0.1973569524817124,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}