{"id":"W4400999779","doi":"10.1007/s00109-024-02470-4","title":"Structure-based humanization of a therapeutic antibody for multiple myeloma","year":2024,"lang":"en","type":"article","venue":"Journal of Molecular Medicine","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"McGill University","keywords":"Multiple myeloma; Human genetics; Molecular medicine; Antibody; Medicine; Computational biology; Immunology; Biology; Cancer; Internal medicine; Genetics; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001526003,0.0002522476,0.0001495394,0.0001021824,0.0001134406,0.0001862893,0.0002535073,0.0003036869,0.001112156],"category_scores_gemma":[0.0001971128,0.0001276482,0.0002753587,0.0001150172,0.0001554846,0.0001396249,0.000171462,0.0005502171,0.0004348234],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003577769,"about_ca_system_score_gemma":0.0003519403,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000541917,"about_ca_topic_score_gemma":0.0005454344,"domain_scores_codex":[0.9999257,0.00001626832,0.000004569808,0.0000135261,0.00003043528,0.000009509865],"domain_scores_gemma":[0.9999478,0.000008683184,0.00001691201,0.00001055241,0.000009473197,0.000006602966],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005724842,0.00002523317,0.0002018474,0.00003624111,0.00001011217,0.00009597523,0.00003468751,0.001891783,0.9936277,0.0004874238,0.00007876576,0.003453094],"study_design_scores_gemma":[0.00002821978,0.0003586022,0.001389538,0.000006769556,0.00002332729,0.0004339633,0.00001609436,0.004150866,0.9869249,0.0002008842,0.006458987,0.000007878538],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9492233,0.001063467,0.04621029,0.0002665144,0.0000524755,0.0001257766,0.0003108096,0.0002635667,0.00248378],"genre_scores_gemma":[0.9453889,0.0009703176,0.04918115,0.0001047806,0.00001035093,0.00004077455,0.0008670342,0.00004567984,0.003390941],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001112156,"threshold_uncertainty_score":0.003720582,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02627960887646174,"score_gpt":0.3660058832713038,"score_spread":0.3397262743948421,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}