{"id":"W4401001439","doi":"10.3389/fimmu.2024.1426232","title":"mRNA lipid nanoparticles expressing cell-surface cleavage independent HIV Env trimers elicit autologous tier-2 neutralizing antibodies","year":2024,"lang":"en","type":"article","venue":"Frontiers in Immunology","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Acuitas Therapeutics (Canada)","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health; International AIDS Vaccine Initiative","keywords":"Gp41; Ectodomain; Neutralizing antibody; Antibody; Cleavage (geology); Virology; Chemistry; Glycoprotein; Molecular biology; Biology; Cell biology; Epitope; Virus; Receptor; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001371637,0.0002980218,0.0001931174,0.0001372208,0.00009649608,0.0002638605,0.0001284449,0.0003652213,0.0007367388],"category_scores_gemma":[0.0001242509,0.0001333068,0.0001836322,0.00006556716,0.0001375982,0.0001750475,0.0001514673,0.0004742454,0.0003112395],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002756087,"about_ca_system_score_gemma":0.0001153416,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003424539,"about_ca_topic_score_gemma":0.0005479345,"domain_scores_codex":[0.9998451,0.00001728337,0.00000910367,0.00003130863,0.00004200307,0.00005524291],"domain_scores_gemma":[0.9999189,0.0000205629,0.00001957495,0.000008275584,0.00001613278,0.00001656196],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003115313,0.00003286155,0.00003766381,0.00001193076,0.000001894192,0.00001382558,0.000009624135,0.00004190005,0.9993142,0.00003418915,0.00002165022,0.0004490127],"study_design_scores_gemma":[0.00001455687,0.0003503427,0.0006239869,0.000002765612,0.00001141425,0.00006922192,0.00001141956,0.0008489169,0.9974433,0.00002024107,0.0006019538,0.000001983734],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995439,0.0002993424,0.002752396,0.00005663029,0.00002707208,0.00002995441,0.00007595284,0.00005956788,0.001260144],"genre_scores_gemma":[0.9958484,0.0001843954,0.001563588,0.00006171403,0.00001079038,0.00002431188,0.0001725323,0.00001699433,0.00211726],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007367388,"threshold_uncertainty_score":0.002464652,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01266476059541386,"score_gpt":0.2541805765020719,"score_spread":0.2415158159066581,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}