{"id":"W4401012408","doi":"10.21203/rs.3.rs-4637657/v1","title":"Pharmacokinetic and pharmacodynamic evaluation of various vasopressin doses and routes in a neonatal piglet model","year":2024,"lang":"en","type":"preprint","venue":"Research Square","topic":"Cardiac Arrest and Resuscitation","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"","keywords":"Vasopressin; Medicine; Pharmacokinetics; Anesthesia; Neonatal resuscitation; Cardiopulmonary resuscitation; Pharmacodynamics; Hemodynamics; Epinephrine; Resuscitation; Pharmacology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000816106,0.0005403435,0.0009120826,0.0002514729,0.0001914695,0.0006504715,0.0003932141,0.0005748977,0.0009401042],"category_scores_gemma":[0.0008603996,0.0002493723,0.0003951971,0.0002299544,0.0006611629,0.0005932002,0.000182056,0.001292662,0.0002216921],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004234724,"about_ca_system_score_gemma":0.0007119401,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007596706,"about_ca_topic_score_gemma":0.0004982352,"domain_scores_codex":[0.9996768,0.00009790238,0.00001569424,0.00007398069,0.00008028722,0.00005522813],"domain_scores_gemma":[0.9995151,0.0001767159,0.0001099521,0.00006174616,0.0000468549,0.00008969014],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0463605,0.003297299,0.002531705,0.0002869313,0.0001585456,0.0003860251,0.0003075473,0.003690999,0.908638,0.0004167948,0.0007920017,0.03313358],"study_design_scores_gemma":[0.001686779,0.1335231,0.01780566,0.00005627999,0.0006099853,0.0008170932,0.0003269983,0.0158568,0.822766,0.0003884505,0.006056311,0.0001066083],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937616,0.001027092,0.003570974,0.0001548736,0.000079261,0.0001679036,0.000452274,0.00007673776,0.0007093851],"genre_scores_gemma":[0.9908675,0.001684248,0.004364732,0.0001733659,0.00006526669,0.0002929843,0.0005819558,0.00004833553,0.001921538],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009401042,"threshold_uncertainty_score":0.004316032,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07152106912762805,"score_gpt":0.4560345651850353,"score_spread":0.3845134960574073,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}