{"id":"W4401013746","doi":"10.1200/go-24-14500","title":"Transcriptomic Features Associated to Neoadjuvant Chemotherapy Response in Four Molecular Breast Cancer Subtypes","year":2024,"lang":"en","type":"article","venue":"JCO Global Oncology","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Chemotherapy; Breast cancer; Transcriptome; Oncology; Medicine; Neoadjuvant therapy; Cancer; Internal medicine; Complete response; Biology; Gene; Genetics; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00034036,0.0002255535,0.0002749832,0.00007582426,0.00003453412,0.00003104229,0.0002022941,0.0005768671,0.0000342071],"category_scores_gemma":[0.00004885437,0.0001992602,0.0001531543,0.0003772332,0.00005610742,0.00000440833,0.00004520843,0.0002368014,0.00003869862],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003981654,"about_ca_system_score_gemma":0.0004611567,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002148746,"about_ca_topic_score_gemma":0.0004060879,"domain_scores_codex":[0.9984444,0.0003053649,0.0002128978,0.0004798291,0.0001235444,0.0004339319],"domain_scores_gemma":[0.9995483,0.00002828259,0.00003498774,0.0001927866,0.00004783474,0.0001478553],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.005903136,0.0001534892,0.002251087,0.00001677014,0.0003073195,0.0007261648,0.000120442,0.0005853434,0.9515561,0.0001542608,0.01413888,0.02408694],"study_design_scores_gemma":[0.008032811,0.006897522,0.5021457,0.0004248242,0.0002729912,0.001760431,0.0001468468,0.0007250255,0.2087099,0.0006305771,0.268579,0.00167439],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9817504,0.007389421,0.000077999,0.008651356,0.0006344492,0.0003249994,0.0001485388,0.00005331764,0.0009694719],"genre_scores_gemma":[0.9964112,0.0003886324,0.0001148147,0.002384788,0.0001248158,0.0000598687,0.00003309875,0.00003127124,0.0004515053],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7428463,"threshold_uncertainty_score":0.8125595,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004627019149990827,"score_gpt":0.290561589177367,"score_spread":0.2859345700273762,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}