{"id":"W4401016895","doi":"10.1371/journal.pone.0304528","title":"Genome wide association study of clinical duration and age at onset of sporadic CJD","year":2024,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Public Health Agency of Canada; Ontario Brain Institute; University of Toronto; University Health Network","funders":"National Institute on Aging; Biogen; Medical Research Council; Robert Koch Institut; University College London; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology; National Institute for Health and Care Research; EU Joint Programme – Neurodegenerative Disease Research; Quest Diagnostics; CurePSP; University College London Hospitals NHS Foundation Trust; Eli Lilly and Company","keywords":"Genome-wide association study; Age of onset; Medicine; Association (psychology); Biology; Genetics; Single-nucleotide polymorphism; Genotype; Pathology; Disease; Gene; Psychology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00158878,0.0003597529,0.0004496454,0.0009374013,0.0005229501,0.0006893609,0.0004298874,0.0007164495,0.001920049],"category_scores_gemma":[0.003589725,0.0002345583,0.0006364189,0.001358195,0.0003439934,0.0002397854,0.0004303784,0.0007434397,0.000248968],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001718019,"about_ca_system_score_gemma":0.0002247112,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003083784,"about_ca_topic_score_gemma":0.003043949,"domain_scores_codex":[0.9988492,0.0003897233,0.00009941401,0.0004353082,0.0001315478,0.00009480788],"domain_scores_gemma":[0.9973853,0.001245076,0.0005317538,0.0002667334,0.0002190268,0.00035209],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00121557,0.00006813341,0.9882733,0.00002816441,0.001024507,0.000531716,0.0001206137,0.0001860749,0.004219892,0.00008322253,0.0002486358,0.004000206],"study_design_scores_gemma":[0.00002640053,0.00009551563,0.9985031,0.000004193575,0.0002005276,0.0004148388,0.00003615669,0.0002800694,0.0001539366,0.00006004708,0.000220589,0.00000465722],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982092,0.000520053,0.0003265743,0.00005129233,0.00001241351,0.00000478147,0.0004265478,0.00001366004,0.0004354886],"genre_scores_gemma":[0.9988087,0.0001341713,0.0002393395,0.00002972447,0.00001475808,0.000006540131,0.0004981381,0.000008032142,0.0002605025],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003083784,"threshold_uncertainty_score":0.008402348,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04280096096419987,"score_gpt":0.2991563639274457,"score_spread":0.2563554029632458,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}