{"id":"W4401020887","doi":"10.3390/curroncol31080315","title":"Early Changes in Alpha-Fetoprotein and Des-γ-Carboxy Prothrombin Are Useful Predictors of Antitumor Response to Durvalumab Plus Tremelimumab Therapy for Advanced Hepatocellular Carcinoma","year":2024,"lang":"en","type":"article","venue":"Current Oncology","topic":"Hepatocellular Carcinoma Treatment and Prognosis","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Fujita Health University","keywords":"Medicine; Tremelimumab; Hepatocellular carcinoma; Internal medicine; Durvalumab; Gastroenterology; Response Evaluation Criteria in Solid Tumors; Oncology; Cancer; Disease; Progressive disease; Immunotherapy","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006646852,0.0002062299,0.0003414387,0.00037556,0.0001143879,0.0003144011,0.0001476615,0.0002245728,0.0003511317],"category_scores_gemma":[0.001252127,0.0001297106,0.0002628787,0.0002551365,0.0001541526,0.0002452441,0.0001741949,0.0003181876,0.0000963531],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001956312,"about_ca_system_score_gemma":0.0001146178,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002776252,"about_ca_topic_score_gemma":0.0005464678,"domain_scores_codex":[0.999733,0.00009983598,0.00004004665,0.00003163688,0.00005497039,0.0000404594],"domain_scores_gemma":[0.9990865,0.0002424015,0.0004374968,0.0000310104,0.00005445709,0.0001481558],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002597543,0.0001141119,0.9859978,0.00001622984,0.00006978034,0.000130837,0.00003338099,0.0002002634,0.002506107,0.00001115158,0.00004133576,0.008281427],"study_design_scores_gemma":[0.00008123904,0.001327813,0.995639,0.00000514709,0.0000662517,0.0004988217,0.00005243126,0.00115368,0.0009404905,0.00002164209,0.0002083434,0.000005058117],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9996651,0.0001823595,0.00003494197,0.00001064756,0.000001375499,0.000002918782,0.0000191889,0.000001398101,0.00008196728],"genre_scores_gemma":[0.9998084,0.00004788082,0.00003611013,0.000005892585,0.000005781334,0.000002981069,0.00005160135,3.61072e-7,0.00004105423],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006646852,"threshold_uncertainty_score":0.003515184,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1357213744175033,"score_gpt":0.3502409150459889,"score_spread":0.2145195406284856,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}