{"id":"W4401028293","doi":"10.1002/cbdv.202400880","title":"Pyrazole, Pyrazoline, and Fused Pyrazole Derivatives: New Horizons in EGFR‐Targeted Anticancer Agents","year":2024,"lang":"en","type":"review","venue":"Chemistry & Biodiversity","topic":"Synthesis and biological activity","field":"Chemistry","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"Discovery Centre","funders":"Indian Council of Medical Research","keywords":"Pyrazole; Erlotinib; Chemistry; Pharmacology; Pharmacophore; Drug; Cancer; Medicine; Epidermal growth factor receptor; Stereochemistry; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001710494,0.0009396226,0.00194809,0.00008658967,0.000166276,0.000132652,0.0007499029,0.001179706,0.002494655],"category_scores_gemma":[0.0001824511,0.0007485651,0.0006213961,0.0005198994,0.0004063805,0.0001159889,0.0008732699,0.001178976,0.0001665396],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004329962,"about_ca_system_score_gemma":0.0003636729,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002093022,"about_ca_topic_score_gemma":0.0000131637,"domain_scores_codex":[0.9969514,0.00003003474,0.0006030813,0.001405182,0.0003326022,0.0006776963],"domain_scores_gemma":[0.9983892,0.000193959,0.0003465296,0.0006077089,0.00004403894,0.0004185539],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001828631,0.001142102,0.008782068,0.08295637,0.001742171,0.0008137922,0.0003223764,4.892616e-7,0.02558849,0.000009863169,0.04408571,0.8343737],"study_design_scores_gemma":[0.0005483249,0.00001544389,0.0002273289,0.00506043,0.00121248,0.00002631722,0.0001288288,0.0000111925,0.01534836,0.00006619471,0.9761038,0.001251304],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.04205464,0.9530606,0.000002362602,0.0001090838,0.0001484917,0.0002430289,0.001586213,0.000246339,0.002549253],"genre_scores_gemma":[0.004643526,0.9925393,0.00007747948,0.00004292703,0.0003682269,0.00001963715,0.000594497,0.0000342881,0.001680098],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9320181,"threshold_uncertainty_score":0.9994965,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06300202333378085,"score_gpt":0.2984248729031256,"score_spread":0.2354228495693448,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}