{"id":"W4401028293","doi":"10.1002/cbdv.202400880","title":"Pyrazole, Pyrazoline, and Fused Pyrazole Derivatives: New Horizons in EGFR‐Targeted Anticancer Agents","year":2024,"lang":"en","type":"review","venue":"Chemistry & Biodiversity","topic":"Synthesis and biological activity","field":"Chemistry","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"Discovery Centre","funders":"Indian Council of Medical Research","keywords":"Pyrazole; Erlotinib; Chemistry; Pharmacology; Pharmacophore; Drug; Cancer; Medicine; Epidermal growth factor receptor; Stereochemistry; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003035473,0.0003832109,0.0004921455,0.0005192594,0.0001900571,0.0005960208,0.0004339038,0.0006378651,0.002113164],"category_scores_gemma":[0.0002015017,0.0002269577,0.0002974047,0.0005777651,0.0003388815,0.001016308,0.0005034481,0.001268483,0.0007211544],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004807663,"about_ca_system_score_gemma":0.0003436748,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006412584,"about_ca_topic_score_gemma":0.001488037,"domain_scores_codex":[0.9998882,0.00001502897,0.000005884592,0.00002795088,0.00003366651,0.00002935051],"domain_scores_gemma":[0.999944,0.0000104542,0.00001373372,0.000002768466,0.00001516921,0.00001399794],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0006330662,0.0007702028,0.00120062,0.006921326,0.00009359044,0.001774359,0.000547118,0.005588471,0.2301572,0.05494425,0.02574697,0.6716228],"study_design_scores_gemma":[0.0002651956,0.00375927,0.003894838,0.0006813212,0.0001343698,0.003241808,0.0002023658,0.00755882,0.08329607,0.009606158,0.8872197,0.0001401882],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.04056289,0.9329731,0.007498332,0.001677939,0.000537428,0.00006982808,0.000251109,0.0001261603,0.0163031],"genre_scores_gemma":[0.2591157,0.7211193,0.006557305,0.001350983,0.0005500804,0.0001097666,0.0004194418,0.00002064538,0.01075676],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002113164,"threshold_uncertainty_score":0.00706923,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06300202333378085,"score_gpt":0.2984248729031256,"score_spread":0.2354228495693448,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}