{"id":"W4401039837","doi":"10.2147/jir.s474707","title":"Interplay of TLR4 and SARS-CoV-2: Unveiling the Complex Mechanisms of Inflammation and Severity in COVID-19 Infections","year":2024,"lang":"en","type":"review","venue":"Journal of Inflammation Research","topic":"COVID-19 Clinical Research Studies","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Institut National de la Recherche Scientifique","funders":"Canadian Institutes of Health Research; Universities Space Research Association","keywords":"TLR4; Inflammation; TLR2; Cytokine storm; Innate immune system; Immunology; Biology; Pattern recognition receptor; Toll-like receptor; Cytokine; Immune system; Receptor; Cell biology; Coronavirus disease 2019 (COVID-19); Disease; Medicine; Genetics; Infectious disease (medical specialty)","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004143908,0.0005455855,0.0009897881,0.00115546,0.0001864546,0.0008688245,0.0004669849,0.0007220106,0.001300781],"category_scores_gemma":[0.0004695209,0.0001840982,0.0005507814,0.000840911,0.0002948208,0.001011479,0.0004955934,0.0009394703,0.0005618768],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003862119,"about_ca_system_score_gemma":0.0007939435,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000612714,"about_ca_topic_score_gemma":0.0007975367,"domain_scores_codex":[0.9998424,0.00003249435,0.00002868522,0.00002977936,0.00004230438,0.00002426007],"domain_scores_gemma":[0.9998498,0.00005030927,0.00002939168,0.000004141958,0.00004630872,0.00001989363],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000423982,0.0001270427,0.002077545,0.03846447,0.000291591,0.0009035506,0.0004385381,0.001584647,0.02366269,0.006997986,0.02910462,0.8959234],"study_design_scores_gemma":[0.00002428228,0.000514392,0.005842519,0.003652259,0.0003766166,0.003018859,0.0003195316,0.0005637732,0.005049838,0.002944861,0.9776191,0.00007396392],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001278313,0.997081,0.0002834717,0.0003622668,0.0002194981,0.000006123426,0.00003420344,0.00001057616,0.0007244787],"genre_scores_gemma":[0.00493668,0.9931132,0.0004114957,0.0003275775,0.0003944964,0.00001233502,0.00008054241,0.000002850345,0.0007208461],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001300781,"threshold_uncertainty_score":0.004351556,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2631731444434278,"score_gpt":0.5754608890470662,"score_spread":0.3122877446036384,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}