{"id":"W4401053505","doi":"10.1016/j.fertnstert.2024.07.029","title":"Prenatal cell-free DNA screening for chromosomal aneuploidies after euploid embryo transfer shows high concordance with preimplantation genetic testing for aneuploidy results and low positive predictive values","year":2024,"lang":"en","type":"article","venue":"Fertility and Sterility","topic":"Prenatal Screening and Diagnostics","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"CReATe Fertility Centre; Sunnybrook Hospital; University of Toronto","funders":"","keywords":"Concordance; Aneuploidy; Embryo; Biology; Genetic testing; Andrology; Ploidy; Embryo transfer; Cell-free fetal DNA; Genetics; Prenatal diagnosis; Obstetrics; Pregnancy; Medicine; Fetus; Chromosome; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002569718,0.0002229884,0.0003334396,0.0008311,0.0002288248,0.0004338864,0.0003800144,0.0004631352,0.0009749574],"category_scores_gemma":[0.01545514,0.0001942057,0.0002528312,0.0006587069,0.0004469125,0.0004392886,0.0004231975,0.0003080313,0.0001746161],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002241657,"about_ca_system_score_gemma":0.0003024551,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001573998,"about_ca_topic_score_gemma":0.001740895,"domain_scores_codex":[0.997684,0.0005824438,0.0002757327,0.000565421,0.0007343222,0.000158132],"domain_scores_gemma":[0.9903069,0.004749953,0.003491334,0.0004823463,0.000702334,0.0002672885],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00008286901,0.00001013468,0.9984356,0.000007848301,0.00002256717,0.00009124836,0.00002553225,0.00003049689,0.0002637372,0.000006306221,0.00001329927,0.001010267],"study_design_scores_gemma":[0.000009632792,0.0002117495,0.9975221,0.000008904332,0.00003225589,0.001201963,0.00007008831,0.0002638716,0.0005732141,0.00001950526,0.00008289273,0.00000390711],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991629,0.0001868721,0.0002579042,0.00001783147,0.000004037943,0.000009673873,0.0001453271,0.000002668184,0.0002128394],"genre_scores_gemma":[0.9995587,0.00005160875,0.0001821579,0.000008864415,0.000004397587,0.000005395446,0.000147832,0.000001110264,0.00003994245],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002569718,"threshold_uncertainty_score":0.01359016,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01723367194962828,"score_gpt":0.2450472750575295,"score_spread":0.2278136031079012,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}