{"id":"W4401067215","doi":"10.1016/s2213-8587(24)00182-7","title":"Efficacy and safety of once-weekly semaglutide 2·4 mg versus placebo in people with obesity and prediabetes (STEP 10): a randomised, double-blind, placebo-controlled, multicentre phase 3 trial","year":2024,"lang":"en","type":"article","venue":"The Lancet Diabetes & Endocrinology","topic":"Diabetes Treatment and Management","field":"Medicine","cited_by":145,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary; LMC Diabetes & Endocrinology (Canada)","funders":"Steno Diabetes Center Aarhus; Novo Nordisk","keywords":"Medicine; Semaglutide; Prediabetes; Placebo; Double blind; Physical therapy; Internal medicine; Diabetes mellitus; Type 2 diabetes; Alternative medicine; Endocrinology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001963488,0.002508196,0.004685775,0.0004779541,0.0004679343,0.00150946,0.001153269,0.002948466,0.008213686],"category_scores_gemma":[0.001777814,0.001016536,0.003316624,0.0003820715,0.001442137,0.001437722,0.0006333457,0.004401116,0.001893023],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000741719,"about_ca_system_score_gemma":0.0009844402,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001318922,"about_ca_topic_score_gemma":0.00227288,"domain_scores_codex":[0.9993511,0.0003039136,0.0000385988,0.000140618,0.00005321054,0.0001125295],"domain_scores_gemma":[0.9990547,0.0003067823,0.0001940419,0.00007626741,0.00005616976,0.0003119467],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9915167,0.002020709,0.0002263951,0.0003174587,0.0006505188,0.0000193045,0.00002532468,0.0001061495,0.001012018,0.000029496,0.0003222363,0.003753703],"study_design_scores_gemma":[0.9714588,0.02634323,0.001225343,0.00002434583,0.0004166936,0.00001197236,0.00001356847,0.0001710647,0.0001219233,0.00006789374,0.0001328574,0.00001237422],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9890701,0.003733674,0.0005234251,0.000674849,0.0007117141,0.001938645,0.00114233,0.000254092,0.00195127],"genre_scores_gemma":[0.9853907,0.002322999,0.001395099,0.00176203,0.0005069055,0.003131379,0.001331948,0.00005512331,0.00410402],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008213686,"threshold_uncertainty_score":0.02747756,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02610063540675881,"score_gpt":0.2991046831145682,"score_spread":0.2730040477078094,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}