{"id":"W4401067215","doi":"10.1016/s2213-8587(24)00182-7","title":"Efficacy and safety of once-weekly semaglutide 2·4 mg versus placebo in people with obesity and prediabetes (STEP 10): a randomised, double-blind, placebo-controlled, multicentre phase 3 trial","year":2024,"lang":"en","type":"article","venue":"The Lancet Diabetes & Endocrinology","topic":"Diabetes Treatment and Management","field":"Medicine","cited_by":145,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary; LMC Diabetes & Endocrinology (Canada)","funders":"Steno Diabetes Center Aarhus; Novo Nordisk","keywords":"Medicine; Semaglutide; Prediabetes; Placebo; Double blind; Physical therapy; Internal medicine; Diabetes mellitus; Type 2 diabetes; Alternative medicine; Endocrinology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006992774,0.0004346916,0.001741197,0.000264841,0.00009754107,0.0000617004,0.000197527,0.0001076475,0.00009113256],"category_scores_gemma":[0.0002154442,0.0002715459,0.0001349033,0.0003116271,0.0003723849,0.0001101411,0.0001940629,0.0003660441,0.00001874924],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009578718,"about_ca_system_score_gemma":0.00009255655,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005501038,"about_ca_topic_score_gemma":0.0002422619,"domain_scores_codex":[0.9970788,0.0002616204,0.0005860357,0.000614271,0.0002651961,0.001194102],"domain_scores_gemma":[0.9963526,0.002763519,0.0001690732,0.0005112279,0.00005373321,0.0001498765],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9707719,0.0008364067,0.009095177,0.000491928,0.002315425,0.00008097535,0.0005907647,0.00002909511,0.0003065887,0.0007095179,0.0005735318,0.01419866],"study_design_scores_gemma":[0.9839041,0.003690567,0.00248835,0.0003446616,0.00236881,0.000006179837,0.0002419271,0.002671779,0.0008444218,0.00004313871,0.003135625,0.0002604815],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.981091,0.005409844,0.000005672826,0.002411498,0.0003354189,0.00794452,0.00003424076,0.0001544219,0.002613416],"genre_scores_gemma":[0.9963784,0.0009447813,0.0002603328,0.000109872,0.0003358969,0.000941839,0.00006103403,0.00004332731,0.0009245374],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01528741,"threshold_uncertainty_score":0.9999737,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02610063540675881,"score_gpt":0.2991046831145682,"score_spread":0.2730040477078094,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}