{"id":"W4401070195","doi":"10.31234/osf.io/ywvh3","title":"Harnessing BDNF Signaling to Promote Resilience in Aging","year":2024,"lang":"en","type":"preprint","venue":"","topic":"Nerve injury and regeneration","field":"Neuroscience","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Lethbridge","funders":"","keywords":"Neuroscience; Neuroprotection; Neurotrophin; Neurotrophic factors; Brain-derived neurotrophic factor; Neuroplasticity; Psychology; Mechanism (biology); Psychological resilience; Aging brain; Synaptic plasticity; Cognition; Medicine; Receptor; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001969299,0.0003022201,0.0003167517,0.0003065068,0.0001698086,0.000542445,0.0001953172,0.0005413414,0.001838772],"category_scores_gemma":[0.0002348591,0.00007964513,0.0002967264,0.0001751677,0.0002802294,0.0004311304,0.0004284334,0.0007774101,0.0006680405],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002930069,"about_ca_system_score_gemma":0.0003907687,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004331783,"about_ca_topic_score_gemma":0.001031539,"domain_scores_codex":[0.9999402,0.00001141261,0.000005120764,0.00001130405,0.00001822734,0.00001374859],"domain_scores_gemma":[0.9999558,0.00001014904,0.000008895447,0.000002791016,0.00001135915,0.00001100265],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009663663,0.0001517731,0.001468185,0.01118959,0.0002661165,0.001825251,0.0005797974,0.001203301,0.469646,0.0342328,0.02035034,0.4581204],"study_design_scores_gemma":[0.0002284468,0.001209843,0.01217653,0.002506803,0.0004499056,0.004246577,0.0004907792,0.002331629,0.2432135,0.03154588,0.7015401,0.00005991],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.1289282,0.8140945,0.02000203,0.008700189,0.002863424,0.0001087014,0.0008352567,0.0005361395,0.02393157],"genre_scores_gemma":[0.39125,0.5839484,0.007304748,0.00167551,0.0009208396,0.00009236324,0.0006259619,0.00006361274,0.01411853],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.001838772,"threshold_uncertainty_score":0.006151319,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04442229813965166,"score_gpt":0.3250934734316635,"score_spread":0.2806711752920119,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}