{"id":"W4401074395","doi":"10.1038/s44222-024-00219-9","title":"Genetically engineered hypoimmunogenic cell therapy","year":2024,"lang":"en","type":"article","venue":"Nature Reviews Bioengineering","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":false,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; University of Toronto; Mount Sinai Hospital","funders":"","keywords":"Immune system; Cell therapy; Immunotherapy; Transplantation; Stem cell; Genetic enhancement; Computational biology; Medicine; Biology; Immunology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002851871,0.0004633653,0.0002704449,0.0002963236,0.00009242836,0.0005015098,0.000486241,0.0006572715,0.001896244],"category_scores_gemma":[0.0001529927,0.0001193887,0.000196204,0.0001599045,0.0005395516,0.0003430013,0.000366975,0.001117978,0.000607996],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003326201,"about_ca_system_score_gemma":0.0001959116,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001696725,"about_ca_topic_score_gemma":0.0002259732,"domain_scores_codex":[0.9998542,0.00002464191,0.000007094189,0.00002609086,0.00006421734,0.0000237025],"domain_scores_gemma":[0.999934,0.00001562083,0.0000227228,0.000009994336,0.0000089316,0.000008694865],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001309194,0.0001478927,0.0001684904,0.0004297521,0.00003684578,0.0002005928,0.00003871966,0.001304801,0.9058639,0.02000353,0.003482847,0.0681918],"study_design_scores_gemma":[0.0001237998,0.0008076065,0.001141017,0.0001514962,0.0001384562,0.001762823,0.00004266217,0.003171897,0.7273363,0.006640714,0.2586557,0.00002748777],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.5000591,0.1903698,0.2258731,0.008178657,0.005143404,0.0004173958,0.001123461,0.00320218,0.0656329],"genre_scores_gemma":[0.8759395,0.06241608,0.03313471,0.002528421,0.0004645479,0.0002985926,0.0007506023,0.0002344748,0.02423307],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.001896244,"threshold_uncertainty_score":0.006343544,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0235477653437189,"score_gpt":0.3134757730102026,"score_spread":0.2899280076664837,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}