{"id":"W4401078421","doi":"10.1186/s13287-024-03819-9","title":"Robust bioprocess design and evaluation of commercial media for the serial expansion of human induced pluripotent stem cell aggregate cultures in vertical-wheel bioreactors","year":2024,"lang":"en","type":"article","venue":"Stem Cell Research & Therapy","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Children's Hospital; Alberta Health Services; Alberta Bone and Joint Health Institute; University of Calgary","funders":"Australasian Gynaecological Endoscopy and Surgery Society; Canadian Institutes of Health Research","keywords":"Bioprocess; Bioreactor; Robustness (evolution); Biochemical engineering; Process engineering; Quality by Design; Induced pluripotent stem cell; Computer science; Biomedical engineering; Biology; Biological system; Biotechnology; Engineering; Embryonic stem cell; Particle size","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002502779,0.0008623719,0.0004416049,0.0007416804,0.00032076,0.00146613,0.0006527095,0.0005284696,0.0007693974],"category_scores_gemma":[0.002034514,0.0002439547,0.0007531748,0.0005776106,0.0003702999,0.0005258179,0.0005854627,0.0005658412,0.0005545224],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009069536,"about_ca_system_score_gemma":0.0007275396,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009549355,"about_ca_topic_score_gemma":0.001497609,"domain_scores_codex":[0.9984075,0.0002376956,0.000286935,0.0002364467,0.0007471432,0.00008425444],"domain_scores_gemma":[0.9987147,0.0002732791,0.0003851715,0.0001001562,0.0004596149,0.00006720307],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001712205,0.0001337928,0.0008654493,0.0002140154,0.00002229788,0.00007301898,0.00006211241,0.002283945,0.9886029,0.0001564649,0.0001196851,0.007295154],"study_design_scores_gemma":[0.00001380742,0.0006762987,0.002251842,0.00002972583,0.00004973702,0.00006136142,0.00004687643,0.00392792,0.9907761,0.00006068604,0.002083767,0.0000219446],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8830967,0.00499438,0.1038374,0.0002913975,0.0001949517,0.001279888,0.002009383,0.0006478379,0.003648065],"genre_scores_gemma":[0.8725564,0.003729303,0.1170571,0.0001625012,0.00005284363,0.001329608,0.002611774,0.0001716468,0.002328869],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002502779,"threshold_uncertainty_score":0.01323617,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.159051984152991,"score_gpt":0.3819695428572124,"score_spread":0.2229175587042214,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}